(2S,3R,4R)-3-(tert-butyldimethylsilyloxy)-2,4-dimethylheptyl benzyl ether

Base Information

Chemical Name:(2S,3R,4R)-3-(tert-butyldimethylsilyloxy)-2,4-dimethylheptyl benzyl ether
CAS No.:137433-88-6
Molecular Formula:C₂₂H₄₀O₂Si
Molecular Weight:364.644
Hs Code.:

Synonyms:(2S,3R,4R)-3-(tert-butyldimethylsilyloxy)-2,4-dimethylheptyl benzyl ether

Suppliers and Price of (2S,3R,4R)-3-(tert-butyldimethylsilyloxy)-2,4-dimethylheptyl benzyl ether

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R,4R)-3-(tert-butyldimethylsilyloxy)-2,4-dimethylheptyl benzyl ether

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Technology Process of (2S,3R,4R)-3-(tert-butyldimethylsilyloxy)-2,4-dimethylheptyl benzyl ether

There total 13 articles about (2S,3R,4R)-3-(tert-butyldimethylsilyloxy)-2,4-dimethylheptyl benzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: (2S,3S,4S)-5-benzyloxy-3-(tert-butyldimethylsilyloxy)-4-methyl-2-propylpentan-1-ol

: 137433-88-6
(2S,3R,4R)-3-(tert-butyldimethylsilyloxy)-2,4-dimethylheptyl benzyl ether

Guidance literature:: (2S,3S,4S)-5-benzyloxy-3-(tert-butyldimethylsilyloxy)-4-methyl-2-propylpentan-1-ol; With trimethylamine hydrochloride; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

With lithium aluminium tetrahydride; rochelle salt; In tetrahydrofuran; dichloromethane; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1039/c6ob01583b

Reference yield:

: C₂₉H₄₆O₅SSi

: 137433-88-6
(2S,3R,4R)-3-(tert-butyldimethylsilyloxy)-2,4-dimethylheptyl benzyl ether

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.tet.2016.07.031

Reference yield:

: (R)-4-benzyl-3-[(2R,3S,4S)-5-benzyloxy-3-hydroxy-4-methyl-2-propylpentanoyl]oxazolidin-2-one

: 137433-88-6
(2S,3R,4R)-3-(tert-butyldimethylsilyloxy)-2,4-dimethylheptyl benzyl ether

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-dimethylpyridine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: lithium borohydride / methanol / 3 h / 0 - 20 °C / Inert atmosphere

3: triethylamine; trimethylamine hydrochloride / dichloromethane / 1 h / 20 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; lithium aluminium tetrahydride; lithium borohydride; trimethylamine hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.tet.2016.07.031