Technology Process of 7-allyl-6-tosyl-6-azaspiro[4.5]decane
There total 9 articles about 7-allyl-6-tosyl-6-azaspiro[4.5]decane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
hexanes; dichloromethane;
at 0 - 20 ℃;
for 2.75h;
Inert atmosphere;
DOI:10.1016/j.tet.2011.04.047
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
2: 3-chloro-benzenecarboperoxoic acid / chloroform / 10 - 20 °C / Inert atmosphere
3: boron trifluoride diethyl etherate / dichloromethane / 0.75 h / -78 °C / Inert atmosphere
4: (triphenylphosphine)copper(I) hydride hexamer / water; benzene / 20 °C / Inert atmosphere
5: ethanol / 20 °C / Inert atmosphere
6: diisobutylaluminium hydride / hexanes; dichloromethane / 2.75 h / 0 - 20 °C / Inert atmosphere
With
(triphenylphosphine)copper(I) hydride hexamer; boron trifluoride diethyl etherate; diisobutylaluminium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
hexanes; ethanol; dichloromethane; chloroform; water; benzene;
2: aza-Achmatowicz rearrangement;
DOI:10.1016/j.tet.2011.04.047
- Guidance literature:
-
Multi-step reaction with 7 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 1 h
2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
3: 3-chloro-benzenecarboperoxoic acid / chloroform / 10 - 20 °C / Inert atmosphere
4: boron trifluoride diethyl etherate / dichloromethane / 0.75 h / -78 °C / Inert atmosphere
5: (triphenylphosphine)copper(I) hydride hexamer / water; benzene / 20 °C / Inert atmosphere
6: ethanol / 20 °C / Inert atmosphere
7: diisobutylaluminium hydride / hexanes; dichloromethane / 2.75 h / 0 - 20 °C / Inert atmosphere
With
(triphenylphosphine)copper(I) hydride hexamer; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; diisobutylaluminium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
hexanes; ethanol; dichloromethane; chloroform; water; ethyl acetate; benzene;
3: aza-Achmatowicz rearrangement;
DOI:10.1016/j.tet.2011.04.047
