methyl 2-(9-(2-((2-nitrophenyl)selanyl)ethyl)-6-oxo-9-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate

Base Information

• Chemical Name: methyl 2-(9-(2-((2-nitrophenyl)selanyl)ethyl)-6-oxo-9-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate
• CAS No.: 1605288-09-2
• Molecular Formula: C₂₅H₂₄N₂O₅Se
• Molecular Weight: 511.436
• Mol file: 1605288-09-2.mol

Synonyms:methyl 2-(9-(2-((2-nitrophenyl)selanyl)ethyl)-6-oxo-9-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate

Chemical Property of methyl 2-(9-(2-((2-nitrophenyl)selanyl)ethyl)-6-oxo-9-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(9-(2-((2-nitrophenyl)selanyl)ethyl)-6-oxo-9-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate

There total 7 articles about methyl 2-(9-(2-((2-nitrophenyl)selanyl)ethyl)-6-oxo-9-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ortho-nitrophenyl selenocyanate (51694-22-5) + methyl 2-(9-(2-hydroxyethyl)-6-oxo-9-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate (1605288-04-7) → methyl 2-(9-(2-((2-nitrophenyl)selanyl)ethyl)-6-oxo-9-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate (1605288-09-2)

Guidance literature:

With trimethylphosphane; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/ol500903e

Reference yield:

methyl 2-(9-(2-(tert-butyldimethylsilyloxy)ethyl)-6-oxo-9-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate (1605288-01-4) → methyl 2-(9-(2-((2-nitrophenyl)selanyl)ethyl)-6-oxo-9-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate (1605288-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / tetrahydrofuran / 1 h / 0 - 20 °C

2: trimethylphosphane / dichloromethane / 0.5 h / 20 °C

With hydrogenchloride; trimethylphosphane; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol500903e

Reference yield:

methyl 2-(1-(4-(2-(tert-butyldimethylsilyloxy)ethyl)hex-4-enoyl)-2-iodo-1H-indol-3-yl)acetate → methyl 2-(9-(2-((2-nitrophenyl)selanyl)ethyl)-6-oxo-9-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate (1605288-09-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,2,2,6,6-pentamethylpiperidine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tris-(o-tolyl)phosphine / acetonitrile / 1 h / 20 °C / Reflux

2: hydrogenchloride / tetrahydrofuran / 1 h / 0 - 20 °C

3: trimethylphosphane / dichloromethane / 0.5 h / 20 °C

With 1,2,2,6,6-pentamethylpiperidine; hydrogenchloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; tris-(o-tolyl)phosphine; trimethylphosphane; In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1021/ol500903e

upstream raw materials:

methyl 2-(9-(2-(tert-butyldimethylsilyloxy)ethyl)-6-oxo-9-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate

ortho-nitrophenyl selenocyanate

methyl 2-(9-(2-hydroxyethyl)-6-oxo-9-vinyl-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate

methyl 6-(tert-butyldimethylsilyloxy)-4-oxohexanoate