N-(3-bromo-1-tosyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzamide

Base Information

• Chemical Name: N-(3-bromo-1-tosyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzamide
• CAS No.: 1225186-99-1
• Molecular Formula: C₂₆H₂₆BrF₂N₅O₇S₃
• Molecular Weight: 734.621
• Mol file: 1225186-99-1.mol

Synonyms:N-(3-bromo-1-tosyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzamide

Chemical Property of N-(3-bromo-1-tosyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-bromo-1-tosyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzamide

There total 4 articles about N-(3-bromo-1-tosyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate (1186193-95-2) + 3-bromo-1-tosyl-1H-pyrazolo[3,4-b]pyridin-5-amine (1186608-70-7) → N-(3-bromo-1-tosyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzamide (1225186-99-1)

Guidance literature:

3-bromo-1-tosyl-1H-pyrazolo[3,4-b]pyridin-5-amine; With trimethylaluminum; In toluene; at 0 - 20 ℃;

methyl 2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate; In toluene; at 90 ℃; for 2h;

Reference yield:

methyl 2,6-difluoro-3-nitrobenzoate (84832-01-9) → N-(3-bromo-1-tosyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzamide (1225186-99-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere of nitrogen

2.1: triethylamine / dichloromethane / 20 °C / Cooling with water bath

3.1: trimethylaluminum / toluene / 0 - 20 °C

3.2: 2 h / 90 °C

With hydrogen; trimethylaluminum; triethylamine; palladium 10% on activated carbon; In ethanol; dichloromethane; toluene;

Reference yield:

2,6-difluoro-3-nitrobenzoic acid (83141-10-0) → N-(3-bromo-1-tosyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzamide (1225186-99-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: methanol; hexane / 2 h / Cooling with cold water

2.1: hydrogen / palladium 10% on activated carbon / ethanol / Inert atmosphere of nitrogen

3.1: triethylamine / dichloromethane / 20 °C / Cooling with water bath

4.1: trimethylaluminum / toluene / 0 - 20 °C

4.2: 2 h / 90 °C

With hydrogen; trimethylaluminum; triethylamine; palladium 10% on activated carbon; In methanol; ethanol; hexane; dichloromethane; toluene;

upstream raw materials:

methyl 2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate

3-bromo-1-tosyl-1H-pyrazolo[3,4-b]pyridin-5-amine

methyl 3-amino-2,6-difluorobenzoate

methyl 2,6-difluoro-3-nitrobenzoate

Downstream raw materials:

N-(3-bromo-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonamido)benzamide

N-(3-cyano-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonamido)benzamide

N-(3-(3-(2-(dimethylamino)ethoxy)phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonamido)benzamide