1-Benzenesulfonyl-2-(1-benzenesulfonyl-1H-pyrrol-3-yl)-4-[1,3]dioxolan-2-yl-butan-2-ol

Base Information

• Chemical Name: 1-Benzenesulfonyl-2-(1-benzenesulfonyl-1H-pyrrol-3-yl)-4-[1,3]dioxolan-2-yl-butan-2-ol
• CAS No.: 146073-01-0
• Molecular Formula: C₂₃H₂₅NO₇S₂
• Molecular Weight: 491.586
• Mol file: 146073-01-0.mol

Synonyms:1-Benzenesulfonyl-2-(1-benzenesulfonyl-1H-pyrrol-3-yl)-4-[1,3]dioxolan-2-yl-butan-2-ol

Chemical Property of 1-Benzenesulfonyl-2-(1-benzenesulfonyl-1H-pyrrol-3-yl)-4-[1,3]dioxolan-2-yl-butan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzenesulfonyl-2-(1-benzenesulfonyl-1H-pyrrol-3-yl)-4-[1,3]dioxolan-2-yl-butan-2-ol

There total 8 articles about 1-Benzenesulfonyl-2-(1-benzenesulfonyl-1H-pyrrol-3-yl)-4-[1,3]dioxolan-2-yl-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(benzenesulfonyl)methyllithium (116511-95-6) + 3-(1,3-dioxolan-2-yl)-1-<1-(phenylsulfonyl)-3-pyrrolyl>-1-propanone (144024-38-4) → 1-Benzenesulfonyl-2-(1-benzenesulfonyl-1H-pyrrol-3-yl)-4-[1,3]dioxolan-2-yl-butan-2-ol (146073-01-0)

Guidance literature:

In tetrahydrofuran; at -78 - -65 ℃; for 0.5h;

DOI:10.1248/cpb.40.2338

Reference yield:

N-phenylsulfonylpyrrole (16851-82-4) → 1-Benzenesulfonyl-2-(1-benzenesulfonyl-1H-pyrrol-3-yl)-4-[1,3]dioxolan-2-yl-butan-2-ol (146073-01-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) AlCl₃ / 1.) 1,2-dichloroethane, 0 deg C, 10 min, 2.) 1,2-dichloroethane, 0 deg C, 1 h

2: 1.) NaH, 2.) 20percent H₂SO₄, 3.) p-TsOH*H₂O

3: 99 percent / tetrahydrofuran / 0.5 h / -78 - -65 °C

With aluminium trichloride; sulfuric acid; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran;

DOI:10.1248/cpb.40.2338

Reference yield:

3-acetyl-1-(phenylsulfonyl)pyrrole (81453-98-7) → 1-Benzenesulfonyl-2-(1-benzenesulfonyl-1H-pyrrol-3-yl)-4-[1,3]dioxolan-2-yl-butan-2-ol (146073-01-0)

Guidance literature:

Multi-step reaction with 6 steps

1: SeO₂ / dioxane; H₂O / 4 h / Heating

2: NaBH₄ / ethanol / 1 h / Ambient temperature

3: aq. NaIO₄ / diethyl ether / 0.67 h / Ambient temperature

4: 98 percent / tetrahydrofuran / 0.17 h / -20 °C

5: 82 percent / MnO₂ / benzene / 1 h / Heating

6: 99 percent / tetrahydrofuran / 0.5 h / -78 - -65 °C

With manganese(IV) oxide; sodium tetrahydroborate; sodium periodate; selenium(IV) oxide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; benzene;

DOI:10.1248/cpb.40.2338

upstream raw materials:

(benzenesulfonyl)methyllithium

3-(1,3-dioxolan-2-yl)-1-<1-(phenylsulfonyl)-3-pyrrolyl>-1-propanone

N-phenylsulfonylpyrrole

3-acetyl-1-(phenylsulfonyl)pyrrole

Downstream raw materials:

1-(phenylsulfonyl)-4-<(phenylsulfonyl)methyl>indole