N2-N,N-dimethylaminomethylene-10-formyl-Pte-Glu(NH(Boc-His(τ-Bu-4-yl)OMe))-OtBu

Base Information

Chemical Name:N2-N,N-dimethylaminomethylene-10-formyl-Pte-Glu(NH(Boc-His(τ-Bu-4-yl)OMe))-OtBu
CAS No.:1071429-55-4
Molecular Formula:C₄₃H₅₈N₁₂O₁₀
Molecular Weight:903.008
Hs Code.:

Synonyms:N2-N,N-dimethylaminomethylene-10-formyl-Pte-Glu(NH(Boc-His(τ-Bu-4-yl)OMe))-OtBu

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Chemical Property of N2-N,N-dimethylaminomethylene-10-formyl-Pte-Glu(NH(Boc-His(τ-Bu-4-yl)OMe))-OtBu

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Technology Process of N2-N,N-dimethylaminomethylene-10-formyl-Pte-Glu(NH(Boc-His(τ-Bu-4-yl)OMe))-OtBu

There total 8 articles about N2-N,N-dimethylaminomethylene-10-formyl-Pte-Glu(NH(Boc-His(τ-Bu-4-yl)OMe))-OtBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1071429-48-5
N(α)-(tert-butoxycarbonyl)-N(Τ)-{4-[(O(α)-tert-butyl-γ-glutamyl)amino]butyl}-L-histidine methyl ester

: 1046806-28-3
N²,N,N-dimethylaminomethylene-10-formyl-pteroic acid

: 1071429-55-4
N2-N,N-dimethylaminomethylene-10-formyl-Pte-Glu(NH(Boc-His(τ-Bu-4-yl)OMe))-OtBu

Guidance literature:: With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1055/s-0028-1083345

Reference yield:

: 1046806-30-7
N(Τ)-(4-aminobutyl)-N(α)-(tert-butoxycarbonyl)-L-histidine methyl ester

: 1071429-55-4
N2-N,N-dimethylaminomethylene-10-formyl-Pte-Glu(NH(Boc-His(τ-Bu-4-yl)OMe))-OtBu

Guidance literature:: Multi-step reaction with 3 steps

1: 1,2-dimethoxyethane / 2 h / 20 °C

2: piperidine / dichloromethane / 3 h / 20 °C

3: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran / 3 h / 20 °C

With piperidine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 1071429-46-3
N(Τ)-(4-azidobutyl)-N(α)-(tert-butoxycarbonyl)-L-histidine methyl ester

: 1071429-55-4
N2-N,N-dimethylaminomethylene-10-formyl-Pte-Glu(NH(Boc-His(τ-Bu-4-yl)OMe))-OtBu

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine / tetrahydrofuran / 19 h / 20 °C

1.2: 4 h

2.1: 1,2-dimethoxyethane / 2 h / 20 °C

3.1: piperidine / dichloromethane / 3 h / 20 °C

4.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran / 3 h / 20 °C

With piperidine; triphenylphosphine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;