(E)-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carbimidoyl cyanide

Base Information

Chemical Name:(E)-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carbimidoyl cyanide
CAS No.:1351237-72-3
Molecular Formula:C₂₆H₂₀N₆OS
Molecular Weight:464.55
Hs Code.:

Synonyms:(E)-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carbimidoyl cyanide

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Chemical Property of (E)-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carbimidoyl cyanide

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Technology Process of (E)-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carbimidoyl cyanide

There total 7 articles about (E)-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carbimidoyl cyanide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.3%

: 872091-00-4
3-(1-cyano-1-methylethyl)benzoic acid

: 1351238-56-6
2-(5-amino-2-methylphenylamino)-2-(thieno[2,3-b]pyrazin-6-yl)acetonitrile

: 1351237-72-3
(E)-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carbimidoyl cyanide

Guidance literature:: 3-(1-cyano-1-methylethyl)benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

2-(5-amino-2-methylphenylamino)-2-(thieno[2,3-b]pyrazin-6-yl)acetonitrile; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 99-55-8
2-methyl-5-nitroaniline

: 1351237-72-3
(E)-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carbimidoyl cyanide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h

1.2: 60 h / 60 °C

2.1: trichlorophosphate / 7 h / 105 °C

3.1: potassium cyanide / acetonitrile; water; tetrahydrofuran / 6 h / 20 °C

4.1: sodium dithionite; ammonia / 1,4-dioxane; water / 4 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 20 °C

With potassium cyanide; sodium dithionite; ammonia; N-ethyl-N,N-diisopropylamine; HATU; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 872091-85-5
methyl 3-(1-cyano-1-methylethyl)benzoate

: 1351237-72-3
(E)-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carbimidoyl cyanide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 20 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1.2: `;