benzoic acid 4-fluorobenzyl ester

Base Information

• Chemical Name: benzoic acid 4-fluorobenzyl ester
• CAS No.: 38612-11-2
• Molecular Formula: C₁₄H₁₁FO₂
• Molecular Weight: 230.239
• Mol file: 38612-11-2.mol

Synonyms:benzoic acid 4-fluorobenzyl ester

Chemical Property of benzoic acid 4-fluorobenzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of benzoic acid 4-fluorobenzyl ester

There total 12 articles about benzoic acid 4-fluorobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-fluorobenzylic alcohol (459-56-3) + benzamide (55-21-0,27208-38-4) → benzoic acid 4-fluorobenzyl ester (38612-11-2)

Guidance literature:

With cerium(IV) oxide; In 1,3,5-trimethyl-benzene; at 165 ℃; for 22h; Inert atmosphere;

DOI:10.1039/c4ra07419j

Reference yield: 83.0%

4-fluorobenzylic alcohol (459-56-3) + 1,3-diphenylpropanedione (120-46-7,61346-73-4) → 4-fluorobenzyl 2-oxo-2-phenylacetate + benzoic acid 4-fluorobenzyl ester (38612-11-2)

Guidance literature:

With pyridine; oxygen; copper(I) bromide; In toluene; at 90 ℃; for 18h; under 760.051 Torr; Schlenk technique;

DOI:10.1021/ja4085463

Reference yield: 72.0%

4-fluorobenzylic alcohol (459-56-3) + N-benzyl-N-(tert-butoxycarbonyl)-benzamide (85909-02-0) → benzoic acid 4-fluorobenzyl ester (38612-11-2)

Guidance literature:

With sodium t-butanolate; In toluene; at 150 ℃; for 24h; Sealed tube;

DOI:10.1007/s11426-020-9883-3

upstream raw materials:

4-fluorobenzylic alcohol

benzeneacetic acid methyl ester

p-fluorotoluene

benzyl alcohol