(+)-1-[3-({(2S)-2-cyclopentyl-2-[4-(trifluoromethyl)phenyl]acetyl}amino)benzyl]cyclopropane-carboxylic acid

Base Information

• Chemical Name: (+)-1-[3-({(2S)-2-cyclopentyl-2-[4-(trifluoromethyl)phenyl]acetyl}amino)benzyl]cyclopropane-carboxylic acid
• CAS No.: 1380604-20-5
• Molecular Formula: C₂₅H₂₆F₃NO₃
• Molecular Weight: 445.482
• Mol file: 1380604-20-5.mol

Synonyms:(+)-1-[3-({(2S)-2-cyclopentyl-2-[4-(trifluoromethyl)phenyl]acetyl}amino)benzyl]cyclopropane-carboxylic acid

Chemical Property of (+)-1-[3-({(2S)-2-cyclopentyl-2-[4-(trifluoromethyl)phenyl]acetyl}amino)benzyl]cyclopropane-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-1-[3-({(2S)-2-cyclopentyl-2-[4-(trifluoromethyl)phenyl]acetyl}amino)benzyl]cyclopropane-carboxylic acid

There total 6 articles about (+)-1-[3-({(2S)-2-cyclopentyl-2-[4-(trifluoromethyl)phenyl]acetyl}amino)benzyl]cyclopropane-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-tert-Butyl 1-[3-({cyclopentyl[4-(trifluoromethyl)phenyl]acetyl}amino)benzyl]cyclopropane-carboxylate (1380605-60-6) → 1-[3-({(2R)-2-cyclopentyl-2-[4-(trifluoromethyl)phenyl]acetyl}amino)benzyl]cyclopropane-carboxylic acid + (+)-1-[3-({(2S)-2-cyclopentyl-2-[4-(trifluoromethyl)phenyl]acetyl}amino)benzyl]cyclopropane-carboxylic acid (1380604-20-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 2h;

Reference yield:

tert-butyl 1-(3-bromobenzyl)cyclopropanecarboxylate (1192039-88-5) → 1-[3-({(2R)-2-cyclopentyl-2-[4-(trifluoromethyl)phenyl]acetyl}amino)benzyl]cyclopropane-carboxylic acid + (+)-1-[3-({(2S)-2-cyclopentyl-2-[4-(trifluoromethyl)phenyl]acetyl}amino)benzyl]cyclopropane-carboxylic acid (1380604-20-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 1.5 h / 110 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 2 h / 20 °C / 760.05 Torr

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; HATU / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

4: trifluoroacetic acid / dichloromethane; water / 2 h / 20 °C

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

meta-bromobenzyl bromide (823-78-9) → 1-[3-({(2R)-2-cyclopentyl-2-[4-(trifluoromethyl)phenyl]acetyl}amino)benzyl]cyclopropane-carboxylic acid + (+)-1-[3-({(2S)-2-cyclopentyl-2-[4-(trifluoromethyl)phenyl]acetyl}amino)benzyl]cyclopropane-carboxylic acid (1380604-20-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 1.5 h / 110 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 2 h / 20 °C / 760.05 Torr

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; HATU / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane; water / 2 h / 20 °C

With n-butyllithium; hydrogen; benzotriazol-1-ol; diisopropylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

meta-bromobenzyl bromide

tert-butyl 1-(3-bromobenzyl)cyclopropanecarboxylate

tert-butyl 1-[3-(benzylamino)benzyl]cyclopropanecarboxylate

tert-butyl 1-(3-aminobenzyl)cyclopropanecarboxylate