(1S)-1-(4-((3R)-1-(5-((2,2-difluorocyclopropyl)methoxy)pyridin-2-yl)pyrrolidin-3-yloxy)phenyl)ethanamine

Base Information

Chemical Name:(1S)-1-(4-((3R)-1-(5-((2,2-difluorocyclopropyl)methoxy)pyridin-2-yl)pyrrolidin-3-yloxy)phenyl)ethanamine
CAS No.:1620690-90-5
Molecular Formula:C₂₁H₂₅F₂N₃O₂
Molecular Weight:389.445
Hs Code.:

Synonyms:(1S)-1-(4-((3R)-1-(5-((2,2-difluorocyclopropyl)methoxy)pyridin-2-yl)pyrrolidin-3-yloxy)phenyl)ethanamine

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Chemical Property of (1S)-1-(4-((3R)-1-(5-((2,2-difluorocyclopropyl)methoxy)pyridin-2-yl)pyrrolidin-3-yloxy)phenyl)ethanamine

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Technology Process of (1S)-1-(4-((3R)-1-(5-((2,2-difluorocyclopropyl)methoxy)pyridin-2-yl)pyrrolidin-3-yloxy)phenyl)ethanamine

There total 3 articles about (1S)-1-(4-((3R)-1-(5-((2,2-difluorocyclopropyl)methoxy)pyridin-2-yl)pyrrolidin-3-yloxy)phenyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620690-83-6
C₂₆H₃₃F₂N₃O₄

: 1620690-90-5
(1S)-1-(4-((3R)-1-(5-((2,2-difluorocyclopropyl)methoxy)pyridin-2-yl)pyrrolidin-3-yloxy)phenyl)ethanamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

: tert-butyl ((S)-1-(4-((R)-pyrrolidin-3-yloxy)phenyl)ethyl)carbamate

: 1620690-90-5
(1S)-1-(4-((3R)-1-(5-((2,2-difluorocyclopropyl)methoxy)pyridin-2-yl)pyrrolidin-3-yloxy)phenyl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium t-butanolate; chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct / 1,4-dioxane / 3 h / 45 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; sodium t-butanolate; In 1,4-dioxane;

Reference yield:

: 1594129-66-4
C₂₅H₃₂N₂O₅

: 1620690-90-5
(1S)-1-(4-((3R)-1-(5-((2,2-difluorocyclopropyl)methoxy)pyridin-2-yl)pyrrolidin-3-yloxy)phenyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2250.23 Torr

2: sodium t-butanolate; chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct / 1,4-dioxane / 3 h / 45 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; palladium 10% on activated carbon; hydrogen; sodium t-butanolate; In 1,4-dioxane; methanol;