tert-butyl-(6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran-2-ylmethoxy)-diphenyl-silane

Base Information

Chemical Name:tert-butyl-(6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran-2-ylmethoxy)-diphenyl-silane
CAS No.:753016-74-9
Molecular Formula:C₂₆H₃₆O₃Si
Molecular Weight:424.656
Hs Code.:

<i>tert</i>-butyl-(6-isopropoxy-3-methyl-3,6-dihydro-2<i>H</i>-pyran-2-ylmethoxy)-diphenyl-silane

Synonyms:tert-butyl-(6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran-2-ylmethoxy)-diphenyl-silane

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Chemical Property of tert-butyl-(6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran-2-ylmethoxy)-diphenyl-silane

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Technology Process of tert-butyl-(6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran-2-ylmethoxy)-diphenyl-silane

There total 9 articles about tert-butyl-(6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran-2-ylmethoxy)-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 67-63-0,8013-70-5
isopropyl alcohol

: 753016-73-8
6-(tert-butyl-diphenyl-silanyloxymethyl)-5-methyl-5,6-dihydro-2H-pyran-2-ol

: 753016-74-9
tert-butyl-(6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran-2-ylmethoxy)-diphenyl-silane

Guidance literature:: With pyridinium p-toluenesulfonate; In benzene;
DOI:10.1021/ol049219z

Reference yield:

: 71565-21-4
(2S,4'R)-(+)-2-(2,2-Dimethyl-1,3-dioxolan-4-yl)-1-propanol

: 753016-74-9
tert-butyl-(6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran-2-ylmethoxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1.1: Dess-Martin periodinane / CH₂Cl₂ / 0 - 20 °C

2.1: PPh₃; Zn powder / CH₂Cl₂ / 24 h / 20 °C

2.2: 440.7 mg / CH₂Cl₂ / 2 h / 20 °C

3.1: BuLi / tetrahydrofuran; hexane / -78 - 20 °C

3.2: 93 percent / tetrahydrofuran / -78 - 20 °C

4.1: 96 percent / H₂ / Lindlar catalyst / methanol / 20 h / 20 °C

5.1: Dowex 50W X₈ / methanol / 7 h / 20 °C

5.2: Amberlyst 15 / CH₂Cl₂ / 12 h / 20 °C

5.3: 57 percent / imidazole / dimethylformamide / 4 h / 20 °C

6.1: 82 percent / DIBAL / CH₂Cl₂ / -78 °C

7.1: 85 percent / PPTS / benzene

With n-butyllithium; Dowex 50W X₈; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; Dess-Martin periodane; triphenylphosphine; zinc; Lindlar's catalyst; In tetrahydrofuran; methanol; hexane; dichloromethane; benzene;
DOI:10.1021/ol049219z

Reference yield:

: 77398-87-9
(2R)-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]propanal

: 753016-74-9
tert-butyl-(6-isopropoxy-3-methyl-3,6-dihydro-2H-pyran-2-ylmethoxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1.1: PPh₃; Zn powder / CH₂Cl₂ / 24 h / 20 °C

1.2: 440.7 mg / CH₂Cl₂ / 2 h / 20 °C

2.1: BuLi / tetrahydrofuran; hexane / -78 - 20 °C

2.2: 93 percent / tetrahydrofuran / -78 - 20 °C

3.1: 96 percent / H₂ / Lindlar catalyst / methanol / 20 h / 20 °C

4.1: Dowex 50W X₈ / methanol / 7 h / 20 °C

4.2: Amberlyst 15 / CH₂Cl₂ / 12 h / 20 °C

4.3: 57 percent / imidazole / dimethylformamide / 4 h / 20 °C

5.1: 82 percent / DIBAL / CH₂Cl₂ / -78 °C

6.1: 85 percent / PPTS / benzene

With n-butyllithium; Dowex 50W X₈; hydrogen; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triphenylphosphine; zinc; Lindlar's catalyst; In tetrahydrofuran; methanol; hexane; dichloromethane; benzene;
DOI:10.1021/ol049219z