(S)-1-amino-N-(1-cyano-2-(4'-((4-(oxazol-2-ylmethyl)piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

Base Information

Chemical Name:(S)-1-amino-N-(1-cyano-2-(4'-((4-(oxazol-2-ylmethyl)piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide
CAS No.:1398718-03-0
Molecular Formula:C₃₁H₃₈N₆O₂
Molecular Weight:526.682
Hs Code.:

Synonyms:(S)-1-amino-N-(1-cyano-2-(4'-((4-(oxazol-2-ylmethyl)piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

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Chemical Property of (S)-1-amino-N-(1-cyano-2-(4'-((4-(oxazol-2-ylmethyl)piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

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Technology Process of (S)-1-amino-N-(1-cyano-2-(4'-((4-(oxazol-2-ylmethyl)piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

There total 4 articles about (S)-1-amino-N-(1-cyano-2-(4'-((4-(oxazol-2-ylmethyl)piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1398718-72-3
PZ₁₀₅₇-2

: 1398718-03-0
(S)-1-amino-N-(1-cyano-2-(4'-((4-(oxazol-2-ylmethyl)piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

Guidance literature:: PZ₁₀₅₇-2; With formic acid; at 0 ℃; for 12h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 91345-62-9
1-(4-bromobenzyl)piperazine

: 1398718-03-0
(S)-1-amino-N-(1-cyano-2-(4'-((4-(oxazol-2-ylmethyl)piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid / methanol / 20 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 1 h / 100 °C / Microwave irradiation

3: formic acid / 12 h / 0 °C

With formic acid; sodium cyanoborohydride; sodium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1122-91-4
4-bromo-benzaldehyde

: 1398718-03-0
(S)-1-amino-N-(1-cyano-2-(4'-((4-(oxazol-2-ylmethyl)piperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium cyanoborohydride; acetic acid / methanol

2: sodium cyanoborohydride; acetic acid / methanol / 20 °C

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 1 h / 100 °C / Microwave irradiation

4: formic acid / 12 h / 0 °C

With formic acid; sodium cyanoborohydride; sodium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; water; N,N-dimethyl-formamide;