3-(2,6-difluorophenylamino)-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one

Base Information

Chemical Name:3-(2,6-difluorophenylamino)-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one
CAS No.:1469991-89-6
Molecular Formula:C₂₄H₁₃F₂N₃O
Molecular Weight:397.384
Hs Code.:

Synonyms:3-(2,6-difluorophenylamino)-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one

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Chemical Property of 3-(2,6-difluorophenylamino)-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one

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Technology Process of 3-(2,6-difluorophenylamino)-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one

There total 4 articles about 3-(2,6-difluorophenylamino)-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 26559-67-1
3-bromo-7H-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one

: 5509-65-9
2,6-difluoroaniline

: 1469991-89-6
3-(2,6-difluorophenylamino)-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In acetonitrile; Reflux;
DOI:10.1016/j.ejmech.2013.07.027

Reference yield:

: 81-86-7
4-bromo-1,8-naphthalenedicarboxylic anhydride

: 1469991-89-6
3-(2,6-difluorophenylamino)-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; potassium hydroxide / tetrahydrofuran / 6 h / Reflux

2: potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate / acetonitrile / Reflux

With bromine; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; potassium hydroxide; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.ejmech.2013.07.027

Reference yield:

: 83-32-9
acenaphthene

: 1469991-89-6
3-(2,6-difluorophenylamino)-benzo[de]benzo[4,5]imidazo[2,1-a]isoquinolin-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium dichromate / acetic acid / 8 h / 75 °C

2: bromine; potassium hydroxide / water / 6 h / 60 °C

3: bromine; potassium hydroxide / tetrahydrofuran / 6 h / Reflux

4: potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate / acetonitrile / Reflux

With sodium dichromate; bromine; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; potassium hydroxide; In tetrahydrofuran; water; acetic acid; acetonitrile;
DOI:10.1016/j.ejmech.2013.07.027