(3S,5R)-2,5-Dimethyl-6-((4S,5R)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexan-3-ol

Base Information

Chemical Name:(3S,5R)-2,5-Dimethyl-6-((4S,5R)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexan-3-ol
CAS No.:916912-89-5
Molecular Formula:C₁₅H₃₀O₃
Molecular Weight:258.401
Hs Code.:

Synonyms:(3S,5R)-2,5-Dimethyl-6-((4S,5R)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexan-3-ol

Suppliers and Price of (3S,5R)-2,5-Dimethyl-6-((4S,5R)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexan-3-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (3S,5R)-2,5-Dimethyl-6-((4S,5R)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexan-3-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,5R)-2,5-Dimethyl-6-((4S,5R)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexan-3-ol

There total 1 articles about (3S,5R)-2,5-Dimethyl-6-((4S,5R)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 38836-21-4,65651-63-0
(S)-4-hydroxy-5-methylhexan-2-one

: 916912-89-5
(3S,5R)-2,5-Dimethyl-6-((4S,5R)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexan-3-ol

Guidance literature:: Multi-step reaction with 11 steps

1.1: 42.55 g / imidazole / dimethylformamide / 24 h

2.1: LDA / hexane; tetrahydrofuran / 0.33 h / -78 °C

2.2: hexane; tetrahydrofuran / 1 h / -78 °C

3.1: 13.85 g / aq. HF / acetonitrile / 20 °C

4.1: H₂ / Pd/C / methanol / 12 h / 20 °C / 760 Torr

5.1: 3.69 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

6.1: pyridine / CH₂Cl₂ / 0 °C

7.1: aq. K₂CO₃ / methanol / 5 h

8.1: 3.64 mg / Dess-Martin reagent / CH₂Cl₂ / 3 h / 0 °C

9.1: CF₃SO₃H; Et₃B; DIPEA / hexane; CH₂Cl₂ / 0.5 h / -10 °C

9.2: 88 percent / TiCl₄ / hexane; CH₂Cl₂ / 2 h

10.1: LiAlH₄ / tetrahydrofuran / 0.5 h / Heating

11.1: PPTs / 24 h

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; triethyl borane; trifluorormethanesulfonic acid; hydrogen fluoride; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2.2: Peterson reaction / 8.1: Dess-Martin oxidation;
DOI:10.1002/chem.200600599

Reference yield:

: 916912-89-5
(3S,5R)-2,5-Dimethyl-6-((4S,5R)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexan-3-ol

: (E)-(2S,3S,5S,7S,10S,16S,19S,22S,27S)-16-((S)-sec-Butyl)-3-hydroxy-7-isopropyl-22-(4-methoxy-benzyl)-2,5,17,19,20,25-hexamethyl-8,29-dioxa-14,17,20,23,30-pentaaza-tricyclo[25.2.1.0^10,14]triaconta-1⁽³⁰⁾,25-diene-9,15,18,21,24-pentaone

Guidance literature:: Multi-step reaction with 10 steps

1: 82 percent / 2,4,6-trichlorobenzoyl chloride; DIPEA; DMAP / benzene

2: TsOH / methanol

3: 2,2,6,6-tetramethylpiperidinyloxyl; KBr; NaHCO₃ / NaClO / CH₂Cl₂; H₂O / 1 h

4: NaClO₂; NaH₂PO₄ / H₂O; 2-methyl-propan-2-ol; various solvent(s) / 1 h

5: HATU; DIPEA / CH₂Cl₂ / 24 h

6: 69 percent / (diethylamino)sulfur trifluoride / CH₂Cl₂ / 3 h / -78 °C

7: N-methylaniline / [Pd(PPh₃)4] / tetrahydrofuran / 2 h

8: HATU; DIPEA / CH₂Cl₂ / 48 h / 20 °C

9: tetrabutylammonium fluoride / tetrahydrofuran

10: HATU; DIPEA / CH₂Cl₂

With dmap; sodium chlorite; sodium dihydrogenphosphate; 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl; diethylamino-sulfur trifluoride; 2,4,6-trichlorobenzoyl chloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; N-methylaniline; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium bromide; sodium hypochlorite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol; benzene;
DOI:10.1002/chem.200600599

Reference yield:

: 916912-89-5
(3S,5R)-2,5-Dimethyl-6-((4S,5R)-2,2,5-trimethyl-[1,3]dioxan-4-yl)-hexan-3-ol

: pyrrolidine-2-carboxylic acid 6-(4-{2-[1-({1-[(1-carboxy-2-methyl-butyl)-methyl-carbamoyl]-ethyl}-methyl-carbamoyl)-2-(4-methoxy-phenyl)-ethylcarbamoyl]-propenyl}-4,5-dihydro-oxazol-2-yl)-5-hydroxy-1-isopropyl-3-methyl-heptyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 82 percent / 2,4,6-trichlorobenzoyl chloride; DIPEA; DMAP / benzene

2: TsOH / methanol

3: 2,2,6,6-tetramethylpiperidinyloxyl; KBr; NaHCO₃ / NaClO / CH₂Cl₂; H₂O / 1 h

4: NaClO₂; NaH₂PO₄ / H₂O; 2-methyl-propan-2-ol; various solvent(s) / 1 h

5: HATU; DIPEA / CH₂Cl₂ / 24 h

6: 69 percent / (diethylamino)sulfur trifluoride / CH₂Cl₂ / 3 h / -78 °C

7: N-methylaniline / [Pd(PPh₃)4] / tetrahydrofuran / 2 h

8: HATU; DIPEA / CH₂Cl₂ / 48 h / 20 °C

9: tetrabutylammonium fluoride / tetrahydrofuran

With dmap; sodium chlorite; sodium dihydrogenphosphate; 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl; diethylamino-sulfur trifluoride; 2,4,6-trichlorobenzoyl chloride; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; N-methylaniline; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; potassium bromide; sodium hypochlorite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol; benzene;
DOI:10.1002/chem.200600599