3-((Z)-1-hydroxy-4-triisopropylsilyloxy-3-trimethylsilylmethyl-but-3-enyl)benzonitrile

Base Information

• Chemical Name: 3-((Z)-1-hydroxy-4-triisopropylsilyloxy-3-trimethylsilylmethyl-but-3-enyl)benzonitrile
• CAS No.: 1043548-37-3
• Molecular Formula: C₂₄H₄₁NO₂Si₂
• Molecular Weight: 431.766
• Mol file: 1043548-37-3.mol

Synonyms:3-((Z)-1-hydroxy-4-triisopropylsilyloxy-3-trimethylsilylmethyl-but-3-enyl)benzonitrile

Chemical Property of 3-((Z)-1-hydroxy-4-triisopropylsilyloxy-3-trimethylsilylmethyl-but-3-enyl)benzonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 3-((Z)-1-hydroxy-4-triisopropylsilyloxy-3-trimethylsilylmethyl-but-3-enyl)benzonitrile

There total 1 articles about 3-((Z)-1-hydroxy-4-triisopropylsilyloxy-3-trimethylsilylmethyl-but-3-enyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-triisopropylsilyloxy-2-trimethylsilylmethyl-propene (924364-53-4) + 3-Cyanobenzaldehyde (24964-64-5) → 3-((Z)-1-hydroxy-4-triisopropylsilyloxy-3-trimethylsilylmethyl-but-3-enyl)benzonitrile (1043548-37-3)

Guidance literature:

With diethylaluminium chloride; In hexane; dichloromethane; at -40 ℃; Inert atmosphere;

DOI:10.1021/ol801183e

Reference yield: 48.0%

trans-Crotonaldehyde (123-73-9,4170-30-3) + 3-((Z)-1-hydroxy-4-triisopropylsilyloxy-3-trimethylsilylmethyl-but-3-enyl)benzonitrile (1043548-37-3) → 3-[(2RS,5SR,6RS)-5-hydroxy-4-methylene-6-((E)-propenyl)-tetrahydropyran-2-yl]-benzonitrile + 3-[(2RS,5SR,6RS)-4-methylene-6-((E)-propenyl)-5-triisopropylsilyloxy-tetrahydropyran-2-yl]-benzonitrile

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -78 - 0 ℃; for 5h; Inert atmosphere;

DOI:10.1021/ol801183e

upstream raw materials:

3-triisopropylsilyloxy-2-trimethylsilylmethyl-propene

3-Cyanobenzaldehyde