N,N'-bis{3-[(4-aminobutyl)amino]propyl}-5-(tert-butyl)-2-hydroxybenzene-1,3-bis[propanamide]

Base Information

Chemical Name:N,N'-bis{3-[(4-aminobutyl)amino]propyl}-5-(tert-butyl)-2-hydroxybenzene-1,3-bis[propanamide]
CAS No.:322638-56-2
Molecular Formula:C₃₀H₅₆N₆O₃
Molecular Weight:548.813
Hs Code.:

Synonyms:N,N'-bis{3-[(4-aminobutyl)amino]propyl}-5-(tert-butyl)-2-hydroxybenzene-1,3-bis[propanamide]

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Chemical Property of N,N'-bis{3-[(4-aminobutyl)amino]propyl}-5-(tert-butyl)-2-hydroxybenzene-1,3-bis[propanamide]

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Technology Process of N,N'-bis{3-[(4-aminobutyl)amino]propyl}-5-(tert-butyl)-2-hydroxybenzene-1,3-bis[propanamide]

There total 9 articles about N,N'-bis{3-[(4-aminobutyl)amino]propyl}-5-(tert-butyl)-2-hydroxybenzene-1,3-bis[propanamide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 364783-94-8
N,N'-bis(4-aminobutyl)-N,N'-bis(3-aminopropyl)-5-(tert-butyl)-2-hydroxybenzene-1,3-bis[propanamide]

: 322638-56-2
N,N'-bis{3-[(4-aminobutyl)amino]propyl}-5-(tert-butyl)-2-hydroxybenzene-1,3-bis[propanamide]

Guidance literature:: With potassium hydride; Trimethylenediamine; at 20 ℃; for 1.5h;
DOI:10.1002/1522-2675(20001108)83:11<3021::AID-HLCA3021>3.0.CO;2-E

Reference yield: 40.0%

: 322638-58-4
2-(benzyloxy)-N,N'-bis(3-{[(tert-butoxy)carbonyl](4-{[(tert-butoxy)carbonyl]amino}butyl)amino}propyl)-5-(tert-butyl)benzene-1,3-bis[propanamide]

: 322638-56-2
N,N'-bis{3-[(4-aminobutyl)amino]propyl}-5-(tert-butyl)-2-hydroxybenzene-1,3-bis[propanamide]

Guidance literature:: 2-(benzyloxy)-N,N'-bis(3-{[(tert-butoxy)carbonyl](4-{[(tert-butoxy)carbonyl]amino}butyl)amino}propyl)-5-(tert-butyl)benzene-1,3-bis[propanamide]; With hydrogen; palladium on activated charcoal; In acetic acid; at 20 ℃; under 2625.21 Torr;

In trifluoroacetic acid; at 20 ℃;
DOI:10.1002/1522-2675(20001108)83:11<3021::AID-HLCA3021>3.0.CO;2-E

Reference yield:

: 34911-36-9
4-(tert-butyl)-2,6-di(prop-2-en-1-yl)phenol

: 322638-56-2
N,N'-bis{3-[(4-aminobutyl)amino]propyl}-5-(tert-butyl)-2-hydroxybenzene-1,3-bis[propanamide]

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide / 1.5 h / 20 °C

1.2: 88 percent / dimethylformamide / 0.5 h / 20 °C

2.1: 9-borabicyclo[3.3.1]nonane / tetrahydrofuran / 3.5 h / 65 °C

2.2: 86 percent / 2N NaOH; 30 percent H₂O₂ / 1.5 h / -50 - 20 °C

3.1: 91 percent / 0.54 M H₂CrO₄ / acetone / 3 h / 20 °C

4.1: 30 percent / 1-methyl-2-chloropyridinium iodide; Et₃N / CH₂Cl₂ / 20 °C

5.1: H₂ / 10 percent Pd/C / acetic acid / 20 °C / 2625.21 Torr

5.2: 40 percent / trifluoroacetic acid / 20 °C

With 2-chloro-1-methyl-pyridinium iodide; hydrogen; chromic acid; sodium hydride; triethylamine; 9-bora-bicyclo[3.3.1]nonane; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1002/1522-2675(20001108)83:11<3021::AID-HLCA3021>3.0.CO;2-E