(R)-3-(N-benzyloxycarbonylpyrrolidin-2-ylmethyl)-7-bromo-5-(methylaminosulfonylmethyl)-1H-indole

Base Information

Chemical Name:(R)-3-(N-benzyloxycarbonylpyrrolidin-2-ylmethyl)-7-bromo-5-(methylaminosulfonylmethyl)-1H-indole
CAS No.:180058-75-7
Molecular Formula:C₂₃H₂₆BrN₃O₄S
Molecular Weight:520.447
Hs Code.:

Synonyms:(R)-3-(N-benzyloxycarbonylpyrrolidin-2-ylmethyl)-7-bromo-5-(methylaminosulfonylmethyl)-1H-indole

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Chemical Property of (R)-3-(N-benzyloxycarbonylpyrrolidin-2-ylmethyl)-7-bromo-5-(methylaminosulfonylmethyl)-1H-indole

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Technology Process of (R)-3-(N-benzyloxycarbonylpyrrolidin-2-ylmethyl)-7-bromo-5-(methylaminosulfonylmethyl)-1H-indole

There total 5 articles about (R)-3-(N-benzyloxycarbonylpyrrolidin-2-ylmethyl)-7-bromo-5-(methylaminosulfonylmethyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: (R)-2-{(E)-3-[(2,6-Dibromo-4-methylsulfamoylmethyl-phenyl)-(2,2,2-trifluoro-acetyl)-amino]-propenyl}-pyrrolidine-1-carboxylic acid benzyl ester

: 180058-75-7
(R)-3-(N-benzyloxycarbonylpyrrolidin-2-ylmethyl)-7-bromo-5-(methylaminosulfonylmethyl)-1H-indole

Guidance literature:: With palladium diacetate; tetrabutyl-ammonium chloride; triethylamine; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; at 80 ℃; for 1h;
DOI:10.1016/0040-4039(96)00322-X

Reference yield:

: (R)-1-(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-[N-(4-methylaminosulfonylmethyl-2,6-dibromophenyl)-N-trifluoroacetylamino]propene

: 1112-67-0
tetrabutyl-ammonium chloride

: 180058-75-7
(R)-3-(N-benzyloxycarbonylpyrrolidin-2-ylmethyl)-7-bromo-5-(methylaminosulfonylmethyl)-1H-indole

Guidance literature:: palladium diacetate; In diethyl ether; dichloromethane; chloroform; triethylamine; N,N-dimethyl-formamide;

Reference yield:

: 109903-35-7
1-(4-aminophenyl)-N-methylmethanesulfonamide

: 180058-75-7
(R)-3-(N-benzyloxycarbonylpyrrolidin-2-ylmethyl)-7-bromo-5-(methylaminosulfonylmethyl)-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / Br₂, NaHCO₃ / methanol / Ambient temperature

2: 84 percent / pyridine / CH₂Cl₂

3: 92 percent / Ph₃P, DEAD / tetrahydrofuran

4: 76 percent / 10 molpercent Pd(OAc)2, NBu₄Cl, triethylamine / dimethylformamide; 1,2-dimethoxy-ethane / 1 h / 80 °C

With pyridine; palladium diacetate; tetrabutyl-ammonium chloride; bromine; sodium hydrogencarbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(96)00322-X