N-(4,4'-DiMethoxytrityl)-8-broMoguanosine 2',3',5'-Triacetate

Base Information

• Chemical Name: N-(4,4'-DiMethoxytrityl)-8-broMoguanosine 2',3',5'-Triacetate
• CAS No.: 1096020-93-7
• Molecular Formula: C₃₇H₃₆BrN₅O₁₀
• Molecular Weight: 790.624
• Mol file: 1096020-93-7.mol

Synonyms:C₃₇H₃₆BrN₅O₁₀

Chemical Property of N-(4,4'-DiMethoxytrityl)-8-broMoguanosine 2',3',5'-Triacetate

Chemical Property:

• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate

Purity/Quality:

97% ^*data from raw suppliers

N-(4,4''-Dimethoxytrityl)-8-bromoguanosine2'',3'',5''-Triacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Guanosine (G837900) derivative. Used as chemical probes in protein S-guanylation by endogenous nitrated nucleosides. N-(4,4'-DiMethoxytrityl)-8-broMoguanosine 2',3',5'-Triacetate can be used as chemical probes in protein S-guanylation by endogenous nitrated nucleosides.

Technology Process of N-(4,4'-DiMethoxytrityl)-8-broMoguanosine 2',3',5'-Triacetate

There total 3 articles about N-(4,4'-DiMethoxytrityl)-8-broMoguanosine 2',3',5'-Triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 2',3',5'.-tri-O-acetyl-8-bromoguanosine (15717-45-0) → C37H36BrN5O10 (1096020-93-7)

Guidance literature:

With pyridine; at 20 ℃; for 10h; Inert atmosphere;

DOI:10.1039/b810771h

Reference yield:

2',3',5'-tri-O-acetyl-guanosine (6979-94-8) → C37H36BrN5O10 (1096020-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine / water / 20 °C

2: pyridine / 8.08 h / 20 °C / Inert atmosphere

With pyridine; bromine; In water;

DOI:10.1080/15257770.2015.1114127

Reference yield:

G (118-00-3) → C37H36BrN5O10 (1096020-93-7)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine; dmap / acetonitrile / 2 h / 20 °C / Cooling with ice

2: bromine / water / 20 °C

3: pyridine / 8.08 h / 20 °C / Inert atmosphere

With pyridine; dmap; bromine; triethylamine; In water; acetonitrile;

DOI:10.1080/15257770.2015.1114127

upstream raw materials:

4,4'-dimethoxytrityl chloride

2',3',5'.-tri-O-acetyl-8-bromoguanosine

2',3',5'-tri-O-acetyl-guanosine

G

Downstream raw materials:

C₃₇H₃₆N₆O₁₂