2-[(4-bromo-2-fluorophenyl)methyl]-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

Base Information

• Chemical Name: 2-[(4-bromo-2-fluorophenyl)methyl]-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid
• CAS No.: 133891-92-6
• Molecular Formula: C₁₈H₁₃BrFNO₄
• Molecular Weight: 406.208

Synonyms:2-[(4-bromo-2-fluorophenyl)methyl]-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

Chemical Property of 2-[(4-bromo-2-fluorophenyl)methyl]-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(4-bromo-2-fluorophenyl)methyl]-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

There total 11 articles about 2-[(4-bromo-2-fluorophenyl)methyl]-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

[2-(4-Bromo-2-fluoro-benzyl)-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetic acid tert-butyl ester (137643-12-0) → 2-[(4-bromo-2-fluorophenyl)methyl]-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid (133891-92-6)

Guidance literature:

With sodium hydroxide; In dichloromethane; for 5h; Ambient temperature;

DOI:10.1002/jhet.5570310254

Reference yield: 65.0%

2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(methoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid (129688-82-0) → 2-[(4-bromo-2-fluorophenyl)methyl]-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid (133891-92-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

2-[(4-bromo-2-fluorophenyl)methyl]-1,2,3,4-tetrahydro-4-(ethoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid → 2-[(4-bromo-2-fluorophenyl)methyl]-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid (133891-92-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol;

upstream raw materials:

[2-(4-Bromo-2-fluoro-benzyl)-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetic acid tert-butyl ester

4-bromo-2-fluorobenzylamine

homophthalic anhydride

2-(2-Chlorocarbonyl-phenyl)-malonic acid dimethyl ester

Downstream raw materials:

[2-(4-Bromo-2-fluoro-benzyl)-4-chloro-1,3-dioxo-1,2,3,4-tetrahydro-isoquinolin-4-yl]-acetyl chloride

2-<(4-bromo-2-fluorophenyl)methyl>-4-chloro-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 133891-92-6 2-[(4-bromo-2-fluorophenyl)methyl]-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolineacetic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send