Technology Process of 5-chloro-2-(4-chloro-2-fluorophenethyl)benzaldehyde
There total 5 articles about 5-chloro-2-(4-chloro-2-fluorophenethyl)benzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-chloro-2-(4-chloro-2-fluorophenethyl)benzonitrile;
With
diisobutylaluminium hydride;
In
hexane; dichloromethane;
at 0 - 20 ℃;
Schlenk technique;
Inert atmosphere;
With
water; hydrogen;
In
hexane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux
2: toluene / 4 h / 140 °C
3: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C
4: palladium on activated charcoal; hydrogen / 24 h / 20 °C / 760.05 Torr
5: diisobutylaluminium hydride / dichloromethane; hexane / 0 - 20 °C / Schlenk technique; Inert atmosphere
With
N-Bromosuccinimide; palladium on activated charcoal; potassium tert-butylate; hydrogen; diisobutylaluminium hydride; dibenzoyl peroxide;
In
tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium tert-butylate / tetrahydrofuran / 3 h / 20 °C
2: palladium on activated charcoal; hydrogen / 24 h / 20 °C / 760.05 Torr
3: diisobutylaluminium hydride / dichloromethane; hexane / 0 - 20 °C / Schlenk technique; Inert atmosphere
With
palladium on activated charcoal; potassium tert-butylate; hydrogen; diisobutylaluminium hydride;
In
tetrahydrofuran; hexane; dichloromethane;
