N-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-hydroxyacetamide

Base Information

Chemical Name:N-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-hydroxyacetamide
CAS No.:1338814-52-0
Molecular Formula:C₃₂H₃₂N₆O₅
Molecular Weight:580.643
Hs Code.:

Synonyms:N-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-hydroxyacetamide

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Chemical Property of N-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-hydroxyacetamide

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Technology Process of N-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-hydroxyacetamide

There total 2 articles about N-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1338814-51-9
N-(4-((4-(3-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)-2-methoxyacetamide

: 1338814-52-0
N-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-hydroxyacetamide

Guidance literature:: N-(4-((4-(3-(3-(tert-butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)-2-methoxyacetamide; With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 3.08333h;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 1229607-39-9
N-(4-((4-aminonaphthalen-1-yl)oxy)pyridin-2-yl)-2-methoxy acetamide

: 227623-26-9
3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-amine

: 1338814-52-0
N-(4-(4-(3-(3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 2 h / 20 °C

1.2: 23 h / 0 - 20 °C / Inert atmosphere

2.1: boron tribromide / dichloromethane / 3.08 h / 0 - 20 °C

With boron tribromide; In dichloromethane;