5-(3-((4S,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

Base Information

Chemical Name:5-(3-((4S,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole
CAS No.:1341155-15-4
Molecular Formula:C₂₂H₃₆N₄O₅SSi
Molecular Weight:496.703
Hs Code.:

Synonyms:5-(3-((4S,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

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Chemical Property of 5-(3-((4S,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

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Technology Process of 5-(3-((4S,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

There total 4 articles about 5-(3-((4S,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1341155-74-5
5-(3-((4S,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylthio)-1-phenyl-1H-tetrazole

: 1341155-15-4
5-(3-((4S,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: With hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; In ethanol; water; at 0 - 20 ℃; for 16h;
DOI:10.1039/c1ob05787a

Reference yield:

: 1341166-65-1
C₁₇H₃₄O₅Si

: 1341155-15-4
5-(3-((4S,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / diethyl ether / 0.33 h / 0 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2.25 h / -20 °C / Inert atmosphere

3: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / ethanol; water / 16 h / 0 - 20 °C

With lithium aluminium tetrahydride; hexaammonium heptamolybdate tetrahydrate; di-isopropyl azodicarboxylate; dihydrogen peroxide; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; water; 2: Mitsunobu reaction;
DOI:10.1039/c1ob05787a

Reference yield:

: 108817-98-7,108818-11-7
ethyl 6-<(tert-butyldimethylsilyl)oxy>-4(S),5(S)-(isopropylidenedioxy)hex-2-enoate

: 1341155-15-4
5-(3-((4S,5S)-5-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)propylsulfonyl)-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 4 steps

1: 5%-palladium/activated carbon; hydrogen / ethanol / 2 h / Inert atmosphere

2: lithium aluminium tetrahydride / diethyl ether / 0.33 h / 0 °C / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2.25 h / -20 °C / Inert atmosphere

4: hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide / ethanol; water / 16 h / 0 - 20 °C

With lithium aluminium tetrahydride; hexaammonium heptamolybdate tetrahydrate; di-isopropyl azodicarboxylate; 5%-palladium/activated carbon; hydrogen; dihydrogen peroxide; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; water; 3: Mitsunobu reaction;
DOI:10.1039/c1ob05787a