1-(1H-indol-3-yl)-2-(2-methoxy-phenyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 1-(1H-indol-3-yl)-2-(2-methoxy-phenyl)-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 1439904-94-5
• Molecular Formula: C₂₄H₂₂N₂O
• Molecular Weight: 354.451
• Mol file: 1439904-94-5.mol

Synonyms:1-(1H-indol-3-yl)-2-(2-methoxy-phenyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property of 1-(1H-indol-3-yl)-2-(2-methoxy-phenyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of 1-(1H-indol-3-yl)-2-(2-methoxy-phenyl)-1,2,3,4-tetrahydroisoquinoline

There total 3 articles about 1-(1H-indol-3-yl)-2-(2-methoxy-phenyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(2-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (3340-37-2) + indole (120-72-9) → 1-(1H-indol-3-yl)-2-(2-methoxy-phenyl)-1,2,3,4-tetrahydroisoquinoline (1439904-94-5)

Guidance literature:

With AIE-active tetraphenylethene-functionalized UiO-isoreticular zirconium metal-organic framework; In methanol; at 20 ℃; for 12h; Irradiation;

DOI:10.1039/c6cc04997d

Reference yield: 73.0%

2-(2-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline (3340-37-2) + indole (120-72-9) + nitrobenzene (98-95-3,26969-40-4) → 1-(1H-indol-3-yl)-2-(2-methoxy-phenyl)-1,2,3,4-tetrahydroisoquinoline (1439904-94-5) + aniline (62-53-3)

Guidance literature:

With Co(dmgH)2Cl₂; Eosin Y; In water; acetonitrile; at 20 ℃; for 36h; Inert atmosphere; Irradiation; Sealed tube;

DOI:10.1002/adsc.201400588

Reference yield: 45.0%

→ 1-(1H-indol-3-yl)-2-(2-methoxy-phenyl)-1,2,3,4-tetrahydroisoquinoline (1439904-94-5)

Guidance literature:

With [Co(dimethylglyoxime)2Cl₂]; Eosin Y; In water; acetonitrile; at 40 ℃; for 16h; Irradiation; Inert atmosphere;

upstream raw materials:

2-(2-methoxyphenyl)-1,2,3,4-tetrahydroisoquinoline

indole

nitrobenzene