2-Aminocyclohexanol

Base Information

• Chemical Name: 2-Aminocyclohexanol
• CAS No.: 931-15-7
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• European Community (EC) Number: 640-699-5
• DSSTox Substance ID: DTXSID60902516
• Nikkaji Number: J81.283H
• Mol file: 931-15-7.mol

Synonyms:2-aminocyclohexanol

Chemical Property of 2-Aminocyclohexanol

Chemical Property:

• Vapor Pressure: 0.0773mmHg at 25°C
• Melting Point: 72-73℃
• Boiling Point: 201.1°Cat760mmHg
• Flash Point: 75.4°C
• PSA: 46.25000
• Density: 1.037g/cm³
• LogP: 0.94890
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 115.099714038
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

97% ^*data from raw suppliers

cis-2-Aminocyclohexanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C(C1)N)O

Technology Process of 2-Aminocyclohexanol

There total 95 articles about 2-Aminocyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trans-1-azido-2-(trimethylsilyloxy)cyclohexane → (+/-)-trans-2-aminocyclohexanol (931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5,931-15-7)

Guidance literature:

With formic acid; Pd/Al₂O₃; In ethyl acetate; at 30 ℃; for 18h; Green chemistry;

DOI:10.1039/c3gc40988k

Reference yield: 96.0%

cyclohexane-1,2-epoxide (286-20-4) → (+/-)-trans-2-aminocyclohexanol (931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5,931-15-7)

Guidance literature:

With ammonium hydroxide; 5 deg C -> 25 deg C, overnight;

DOI:10.1002/ardp.19933260711

Reference yield: 95.0%

trans-2-azido-1-cyclohexanol → (+/-)-trans-2-aminocyclohexanol (931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5,931-15-7)

Guidance literature:

With sodium tetrahydroborate; cetyltrimethylammonim bromide; cobalt(II) chloride; In water; at 25 ℃; for 0.166667h;

DOI:10.1055/s-2000-6389

upstream raw materials:

(+/-)-trans-2-aminocyclohexanol

(1R,2R)-trans-2-azidocyclohexanol

(1R,2R)-trans-2-(N-tert-butyloxycarbonyl)amino-1-cyclohexanol

(1R,2R)-trans-2-[(R)-(α-methylbenzyl)amino]cyclohexanol

Downstream raw materials:

N.N'-bis-((1R)-trans-2-hydroxy-cyclohexyl)-ethylenediamine

((1R)-trans-2-hydroxy-cyclohexyl)-trimethyl-ammonium; iodide

5-((1R,2R)-2-Hydroxy-cyclohexyl)-1,3-dimethyl-[1,3,5]triazinan-2-one

trans-(-)-2-(dimethylamino)cyclohexanol