methyl 5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-(methylthio)pyrimidine-4-carboxylate

Base Information

• Chemical Name: methyl 5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-(methylthio)pyrimidine-4-carboxylate
• CAS No.: 1292286-48-6
• Molecular Formula: C₁₄H₁₁Cl₂FN₂O₃S
• Molecular Weight: 377.223

Synonyms:methyl 5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-(methylthio)pyrimidine-4-carboxylate

Chemical Property of methyl 5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-(methylthio)pyrimidine-4-carboxylate

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Technology Process of methyl 5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-(methylthio)pyrimidine-4-carboxylate

There total 2 articles about methyl 5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-(methylthio)pyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-(4-chloro-2-fluoro-3-methoxyphenyl)-4,5-dichloro-6-methoxycarbonyl-pyrimidine (1165931-74-7) + sodium thiomethoxide (5188-07-8) → methyl 5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-(methylthio)pyrimidine-4-carboxylate (1292286-48-6)

Guidance literature:

In methanol; at 20 ℃; for 1h;

Reference yield:

methyl 2-bromo-5-chloro-6-(methylthio)pyrimidine-4-carboxylate (944128-96-5) + (4-chloro-2-fluoro-3-methoxyphenyl)-boronic acid (944129-07-1) → methyl 5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-(methylthio)pyrimidine-4-carboxylate (1292286-48-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In 1,4-dioxane; for 4h; Reflux;

Reference yield: 60.0%

methyl 5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-(methylthio)pyrimidine-4-carboxylate (1292286-48-6) → methyl 5-chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-(methylsulfonyl)pyrimidine-4-carboxylate

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃;

upstream raw materials:

2-(4-chloro-2-fluoro-3-methoxyphenyl)-4,5-dichloro-6-methoxycarbonyl-pyrimidine

sodium thiomethoxide

methyl 2-bromo-5-chloro-6-(methylthio)pyrimidine-4-carboxylate

(4-chloro-2-fluoro-3-methoxyphenyl)-boronic acid

Downstream raw materials:

(Z)-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-methoxycarbonyl-5-(prop-1-enyl)-4-thiomethyl-pyrimidine

(Z)-4-azido-2-(4-chloro-2-fluoro-3-methoxyphenyl)-6-methoxycarbonyl-5-(prop-1-enyl)-pyrimidine

2-(4-chloro-2-fluoro-3-methoxyphenyl)-4-methoxycarbonyl-6-methyl-7H-pyrrolo[2,3-d]pyrimidine

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