2-(benzyloxy)-6-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]-3-methylpyridine

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Chemical Name:2-(benzyloxy)-6-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]-3-methylpyridine
CAS No.:1189757-73-0
Molecular Formula:C₂₈H₂₄F₂N₄O
Molecular Weight:470.522
Hs Code.:

Synonyms:2-(benzyloxy)-6-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]-3-methylpyridine

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Chemical Property of 2-(benzyloxy)-6-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]-3-methylpyridine

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Technology Process of 2-(benzyloxy)-6-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]-3-methylpyridine

There total 1 articles about 2-(benzyloxy)-6-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]-3-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 498538-91-3
(1S,2S)-1-(4-fluorophenyl)-1-(6-fluoro-pyridin-3-yl)-1,2-propanediamine

: 6-(benzyloxy)-5-methylpyridine-2-carbonitrile

: 1189757-73-0
2-(benzyloxy)-6-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]-3-methylpyridine

Guidance literature:: 6-(benzyloxy)-5-methylpyridine-2-carbonitrile; With sodium methylate; In methanol; at 20 - 50 ℃;

With methanesulfonic acid; In methanol;

(1S,2S)-1-(4-fluorophenyl)-1-(6-fluoro-pyridin-3-yl)-1,2-propanediamine; In methanol; at 80 ℃;
DOI:10.1016/j.bmc.2009.05.069

Reference yield: 61.0%

: 1189757-73-0
2-(benzyloxy)-6-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]-3-methylpyridine

: 1189757-78-5
6-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]-3-methylpyridin-2(1H)-one

Guidance literature:: 2-(benzyloxy)-6-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]-3-methylpyridine; With trifluoroacetic acid; at 20 ℃; for 48h;

With sodium hydrogencarbonate; In water;
DOI:10.1016/j.bmc.2009.05.069