Methyl <3aα,7aβ>-3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-octahydro-2-(phenylmethylene)-3aH-indene-3a-carboxylate

Base Information

Chemical Name:Methyl <3aα,7aβ>-3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-octahydro-2-(phenylmethylene)-3aH-indene-3a-carboxylate
CAS No.:130082-98-3
Molecular Formula:C₂₄H₃₆O₃Si
Molecular Weight:400.634
Hs Code.:

Synonyms:Methyl <3aα,7aβ>-3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-octahydro-2-(phenylmethylene)-3aH-indene-3a-carboxylate

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Chemical Property of Methyl <3aα,7aβ>-3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-octahydro-2-(phenylmethylene)-3aH-indene-3a-carboxylate

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Technology Process of Methyl <3aα,7aβ>-3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-octahydro-2-(phenylmethylene)-3aH-indene-3a-carboxylate

There total 11 articles about Methyl <3aα,7aβ>-3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-octahydro-2-(phenylmethylene)-3aH-indene-3a-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 130082-97-2
Methyl <1α,2α>-1-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-phenyl-2-propynyl>-2-<(phenylseleno)methyl>cyclohexanecarboxylate

: 130082-98-3
Methyl <3aα,7aβ>-3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-octahydro-2-(phenylmethylene)-3aH-indene-3a-carboxylate

Guidance literature:: With 2,2'-azobis(isobutyronitrile); triphenylstannane; In benzene; Heating;
DOI:10.1039/c39900000972

Reference yield:

: 130082-95-0,130144-65-9
<3aα,7aα>-Hexahydro-7a-(1-hydroxy-3-phenyl-2-propynyl)-1(3H)-isobenzofuranone

: 130082-98-3
Methyl <3aα,7aβ>-3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-octahydro-2-(phenylmethylene)-3aH-indene-3a-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / Et₃N, DMAP / dimethylformamide / 1.) 66 h, 2.) 50 deg C, 24 h

2: NaH / 1.) THF, reflux, 50 min, 2.) THF, HMPA, reflux, 12 h

3: diethyl ether

4: 78 percent / Ph₃SnH, AIBN / benzene / Heating

With dmap; 2,2'-azobis(isobutyronitrile); triphenylstannane; sodium hydride; triethylamine; In diethyl ether; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00076a057

Reference yield:

: 130082-96-1,130144-66-0
<3aα,7aα>-7a-<1-<<(1,1-Dimethylethyl)dimethylsilyl>oxy>-3-phenyl-2-propynyl>hexahydro-1(3H)-isobenzofuranone

: 130082-98-3
Methyl <3aα,7aβ>-3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-octahydro-2-(phenylmethylene)-3aH-indene-3a-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / 1.) THF, reflux, 50 min, 2.) THF, HMPA, reflux, 12 h

2: diethyl ether

3: 78 percent / Ph₃SnH, AIBN / benzene / Heating

With 2,2'-azobis(isobutyronitrile); triphenylstannane; sodium hydride; In diethyl ether; benzene;
DOI:10.1021/jo00076a057