[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]acetic acid

Base Information

Chemical Name:[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]acetic acid
CAS No.:126655-10-5
Molecular Formula:C17H16 O8
Molecular Weight:348.309
Hs Code.:
Mol file:126655-10-5.mol

Synonyms:2H-1-Benzopyran-4-aceticacid, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-3,5,7-trihydroxy-, [2R-(2a,3a,4b)]-; 4b-Carboxymethyl-(-)-epicatechin;Dryopteric acid

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]acetic acid

Chemical Property:

Vapor Pressure:1.3E-23mmHg at 25°C
Boiling Point:749.7°C at 760 mmHg
PKA:4.44±0.10(Predicted)
Flash Point:278.6°C
PSA：147.68000
Density:1.636g/cm³
LogP:1.56190

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of [2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]acetic acid

There total 7 articles about [2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 478241-22-4
[(2R,3R,4S)-3,5,7-Tris-benzyloxy-2-(3,4-bis-benzyloxy-phenyl)-chroman-4-yl]-acetic acid benzyl ester

: 126655-10-5
4β-carboxymethyl-(-)-epicatechin

Guidance literature:: With hydrogen; palladium dihydroxide; In tetrahydrofuran; methanol; at 25 ℃; for 21h;
DOI:10.1016/S0040-4039(02)01826-9

Reference yield:

: 87292-49-7
5,7,3',4'-tetra-O-benzylepicatechin

: 126655-10-5
4β-carboxymethyl-(-)-epicatechin

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / NaH / dimethylformamide / 4 h / 25 °C

2: 51 percent / DDQ / CH₂Cl₂

3: 95 percent / BF₃*OEt₂ / CH₂Cl₂ / 1 h / -78 °C

4: 100 percent / H₂ / Pd(OH)2/C / tetrahydrofuran; methanol / 21 h / 25 °C

With boron trifluoride diethyl etherate; hydrogen; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(02)01826-9

Reference yield:

: 301539-02-6
3,5,7,3',4'-penta-O-benzylepicatechin

: 126655-10-5
4β-carboxymethyl-(-)-epicatechin

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / DDQ / CH₂Cl₂

2: 95 percent / BF₃*OEt₂ / CH₂Cl₂ / 1 h / -78 °C

3: 100 percent / H₂ / Pd(OH)2/C / tetrahydrofuran; methanol / 21 h / 25 °C

With boron trifluoride diethyl etherate; hydrogen; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(02)01826-9