tert-butyldimethyl((S)-1-((S)-oxiran-2-yl)-3-phenylpropan-2-yloxy)silane

Base Information

Chemical Name:tert-butyldimethyl((S)-1-((S)-oxiran-2-yl)-3-phenylpropan-2-yloxy)silane
CAS No.:1374151-55-9
Molecular Formula:C₁₇H₂₈O₂Si
Molecular Weight:292.494
Hs Code.:

Synonyms:tert-butyldimethyl((S)-1-((S)-oxiran-2-yl)-3-phenylpropan-2-yloxy)silane

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Chemical Property of tert-butyldimethyl((S)-1-((S)-oxiran-2-yl)-3-phenylpropan-2-yloxy)silane

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Technology Process of tert-butyldimethyl((S)-1-((S)-oxiran-2-yl)-3-phenylpropan-2-yloxy)silane

There total 4 articles about tert-butyldimethyl((S)-1-((S)-oxiran-2-yl)-3-phenylpropan-2-yloxy)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₂₈O₂Si

: 1374151-55-9
tert-butyldimethyl((S)-1-((S)-oxiran-2-yl)-3-phenylpropan-2-yloxy)silane

: 1374151-56-0
(2R,4S)-4-(tert-butyldimethylsilyloxy)-5-phenylpentane-1,2-diol

Guidance literature:: With (S,S)-(+)-N,N’-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminomanganese(III) chloride; water; In tetrahydrofuran; at 0 - 20 ℃; for 16h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol300707j

Reference yield:

: C₁₁H₁₄O₂

: 1374151-55-9
tert-butyldimethyl((S)-1-((S)-oxiran-2-yl)-3-phenylpropan-2-yloxy)silane

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: (S,S)-(+)-N,N’-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminomanganese(III) chloride; water / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; (S,S)-(+)-N,N’-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminomanganese(III) chloride; water; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Jacobsen hydrolytic kinetic resolution;
DOI:10.1021/ol300707j

Reference yield:

: 122-78-1
phenylacetaldehyde

: 1374151-55-9
tert-butyldimethyl((S)-1-((S)-oxiran-2-yl)-3-phenylpropan-2-yloxy)silane

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether; pentane / 0.5 h / -100 - -78 °C / Inert atmosphere

2: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

3: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

4: (S,S)-(+)-N,N’-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminomanganese(III) chloride; water / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; (S,S)-(+)-N,N’-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminomanganese(III) chloride; water; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; pentane; 1: Brown allylation / 4: Jacobsen hydrolytic kinetic resolution;
DOI:10.1021/ol300707j