(2S,3R)-3-<(tert-butyldimethylsilyl)oxy>-N-(2,4-dimethoxybenzyl)-2-(phenylthiomethyl)butanamide

Base Information

• Chemical Name: (2S,3R)-3-<(tert-butyldimethylsilyl)oxy>-N-(2,4-dimethoxybenzyl)-2-(phenylthiomethyl)butanamide
• CAS No.: 137528-04-2
• Molecular Formula: C₂₆H₃₉NO₄SSi
• Molecular Weight: 489.751

Synonyms:(2S,3R)-3-<(tert-butyldimethylsilyl)oxy>-N-(2,4-dimethoxybenzyl)-2-(phenylthiomethyl)butanamide

Chemical Property of (2S,3R)-3-<(tert-butyldimethylsilyl)oxy>-N-(2,4-dimethoxybenzyl)-2-(phenylthiomethyl)butanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-3-<(tert-butyldimethylsilyl)oxy>-N-(2,4-dimethoxybenzyl)-2-(phenylthiomethyl)butanamide

There total 2 articles about (2S,3R)-3-<(tert-butyldimethylsilyl)oxy>-N-(2,4-dimethoxybenzyl)-2-(phenylthiomethyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

ethyl (3R)-3-<(tert-butyldimethylsilyl)oxy>-2-(phenylthiomethyl)butanoate (130164-35-1,130164-36-2) + 2,4-dimethoxybenzylamine hydrochloride (20781-21-9) → (2S,3R)-3-<(tert-butyldimethylsilyl)oxy>-N-(2,4-dimethoxybenzyl)-2-(phenylthiomethyl)butanamide (137528-04-2)

Guidance literature:

With trimethylaluminum; In benzene; for 72h; Heating;

DOI:10.1039/c39900000727

Reference yield:

ethyl (3R)-3-<(tert-butyldimethylsilyl)oxy>-2-(phenylthiomethyl)butanoate (130164-35-1,130164-36-2) + 2,4-dimethoxybenzylamine hydrochloride (20781-21-9) → (2S,3R)-3-<(tert-butyldimethylsilyl)oxy>-N-(2,4-dimethoxybenzyl)-2-(phenylthiomethyl)butanamide (137528-04-2) + (2R,3R)-3-<(tert-butyldimethylsilyl)oxy>-N-(2,4-dimethoxybenzyl)-2-(phenylthiomethyl)butanamide (137547-48-9)

Guidance literature:

With trimethylaluminum; Yield given. Multistep reaction. Yields of byproduct given; 1.) hexane, benzene, from 0 deg C to RT, 1 h, 2.) hexane, benzene, reflux, 3 d;

DOI:10.1248/cpb.40.12

Reference yield: 89.0%

(2S,3R)-3-<(tert-butyldimethylsilyl)oxy>-N-(2,4-dimethoxybenzyl)-2-(phenylthiomethyl)butanamide (137528-04-2) → (2S,3R)-3-<(tert-butyldimethylsilyl)oxy>-N-(2,4-dimethoxybenzyl)-2-(phenylsulfinylmethyl)butanamide (137528-07-5)

Guidance literature:

With sodium periodate; In methanol; at 20 ℃; for 24h;

DOI:10.1039/c39900000727

upstream raw materials:

ethyl (3R)-3-<(tert-butyldimethylsilyl)oxy>-2-(phenylthiomethyl)butanoate

2,4-dimethoxybenzylamine hydrochloride

Downstream raw materials:

(2S,3R)-3-<(tert-butyldimethylsilyl)oxy>-N-(2,4-dimethoxybenzyl)-2-(phenylsulfinylmethyl)butanamide

<3S-<3α(S^*),4β>>-benzyl<3-(1-t-butyldimethylsilyloxyethyl)-2-azetidinone-4-yl>acetate

<3S-<3α(S^*),4β>>-benzyl<1-(2,4-dimethoxybenzyl)-3-(1-t-butyldimethylsilyloxyethyl)-2-azetidinone-4-yl>acetate

(3S,4S)-3-<(R)-1-<(tert-butyldimethylsilyl)oxy>ethyl>-1-(2,4-dimethoxybenzyl)-4-(phenylthio)azetidin-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 137528-04-2 (2S,3R)-3-<(tert-butyldimethylsilyl)oxy>-N-(2,4-dimethoxybenzyl)-2-(phenylthiomethyl)butanamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send