2-cyclohexylethynylbenzyl alcohol

Base Information

• Chemical Name: 2-cyclohexylethynylbenzyl alcohol
• CAS No.: 1319735-03-9
• Molecular Formula: C₁₅H₁₈O
• Molecular Weight: 214.307
• Mol file: 1319735-03-9.mol

Synonyms:2-cyclohexylethynylbenzyl alcohol

Chemical Property of 2-cyclohexylethynylbenzyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyclohexylethynylbenzyl alcohol

There total 1 articles about 2-cyclohexylethynylbenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-cyclohexylacetylene (931-48-6) + 2-iodobenzyl alcohol (5159-41-1) → 2-cyclohexylethynylbenzyl alcohol (1319735-03-9)

Guidance literature:

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In toluene; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1039/c1cc13094c

Reference yield: 45.0%

2-cyclohexylethynylbenzyl alcohol (1319735-03-9) → 2-cyclohexylethynylbenzyl bromide (1319735-07-3)

Guidance literature:

With pyridine; phosphorus tribromide; In chloroform; at 0 - 20 ℃;

DOI:10.1039/c1cc13094c

Reference yield:

2-cyclohexylethynylbenzyl alcohol (1319735-03-9) → 1-(2-cyclohexylethynylbenzyl)-1H-indole (1319735-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; phosphorus tribromide / chloroform / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

With pyridine; phosphorus tribromide; sodium hydride; In chloroform; N,N-dimethyl-formamide; mineral oil;

DOI:10.1039/c1cc13094c

upstream raw materials:

2-cyclohexylacetylene

2-iodobenzyl alcohol

Downstream raw materials:

2-cyclohexylethynylbenzyl bromide

1-(2-cyclohexylethynylbenzyl)-1H-indole

1-(2-pent-1-ynylbenzyl)-1H-pyrrole