1-(bromoethynyl)-2-(cyclopropylidenemethyl)-4-fluorobenzene

Base Information

• Chemical Name: 1-(bromoethynyl)-2-(cyclopropylidenemethyl)-4-fluorobenzene
• CAS No.: 1443931-37-0
• Molecular Formula: C₁₂H₈BrF
• Molecular Weight: 251.098
• Mol file: 1443931-37-0.mol

Synonyms:1-(bromoethynyl)-2-(cyclopropylidenemethyl)-4-fluorobenzene

Chemical Property of 1-(bromoethynyl)-2-(cyclopropylidenemethyl)-4-fluorobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(bromoethynyl)-2-(cyclopropylidenemethyl)-4-fluorobenzene

There total 1 articles about 1-(bromoethynyl)-2-(cyclopropylidenemethyl)-4-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-(cyclopropylidenemethyl)-1-ethynyl-4-fluorobenzene (1309565-91-0) → 1-(bromoethynyl)-2-(cyclopropylidenemethyl)-4-fluorobenzene (1443931-37-0)

Guidance literature:

With N-Bromosuccinimide; silver nitrate; In acetone; at 20 ℃;

DOI:10.1002/adsc.201200374

Reference yield: 65.0%

4-methyl-N-(2-propenyl)benzenesulfonamide (50487-71-3) + 1-(bromoethynyl)-2-(cyclopropylidenemethyl)-4-fluorobenzene (1443931-37-0) → 9-allyl-6-fluoro-1-tosyl-2,3-dihydro-1H-benzo[f]indole (1443931-43-8)

Guidance literature:

With 1,10-Phenanthroline; copper diacetate; potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; Inert atmosphere;

DOI:10.1002/adsc.201200374

upstream raw materials:

2-(cyclopropylidenemethyl)-1-ethynyl-4-fluorobenzene

Downstream raw materials:

9-allyl-6-fluoro-1-tosyl-2,3-dihydro-1H-benzo[f]indole