N-[2-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl}sulfanyl)ethyl]acetamide

Base Information

Chemical Name:N-[2-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl}sulfanyl)ethyl]acetamide
CAS No.:1356354-09-0
Molecular Formula:C₁₈H₁₆F₃N₃O₃S₂
Molecular Weight:443.471
Hs Code.:

Synonyms:N-[2-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl}sulfanyl)ethyl]acetamide

Suppliers and Price of N-[2-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl}sulfanyl)ethyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
T3364366 ≥98%(HPLC)
50
$ 704.00

Tocris
T3364366 ≥98%(HPLC)
10
$ 168.00

Biosynth Carbosynth
T 3364366 NEW
10 mg
$ 105.00

Biosynth Carbosynth
T 3364366 NEW
50 mg
$ 367.50

AK Scientific
N-[2-[4-Oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]thieno[3,4-d]pyrimidin-2-yl]sulfanylethyl]acetamide
10mg
$ 191.00

Total 5 raw suppliers

Chemical Property of N-[2-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl}sulfanyl)ethyl]acetamide

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

T3364366 ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[2-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl}sulfanyl)ethyl]acetamide

There total 7 articles about N-[2-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl}sulfanyl)ethyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[(2-aminoethyl)sulfanyl]-3-[4-(2,2,2-trifluoroethoxy)phenyl]thieno[3,4-d]pyrimidin-4(3H)-one hydrochloride

: 108-24-7
acetic anhydride

: 1356354-09-0
N-[2-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl}sulfanyl)ethyl]acetamide

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 2-[(2-aminoethyl)sulfanyl]-3-[4-(2,2,2-trifluoroethoxy)phenyl]thieno[3,4-d]pyrimidin-4(3H)-one hydrochloride

: 108-24-7
acetic anhydride

: 1356354-09-0
N-[2-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl}sulfanyl)ethyl]acetamide

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1021/acsmedchemlett.6b00241

Reference yield:

: 69363-85-5
methyl 4-aminothiophene-3-carboxylate

: 1356354-09-0
N-[2-({4-oxo-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,4-dihydrothieno[3,4-d]pyrimidin-2-yl}sulfanyl)ethyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 1 h / 0 - 20 °C

2.1: acetonitrile / 2 h / Reflux

2.2: 0.5 h / Reflux

2.3: 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Cooling with ice

4.1: hydrogenchloride / ethyl acetate; methanol / 14 h / 20 °C

5.1: triethylamine; dmap / tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; dmap; sodium hydride; triethylamine; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1021/acsmedchemlett.6b00241