1-cyclohexyl-6-tosyl-2- (trifluoromethyl)-1,6- dihydroimidazo[4,5-d]pyrrolo[2,3- b]pyridine

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Chemical Name:1-cyclohexyl-6-tosyl-2- (trifluoromethyl)-1,6- dihydroimidazo[4,5-d]pyrrolo[2,3- b]pyridine
CAS No.:1310732-76-3
Molecular Formula:C₂₂H₂₁F₃N₄O₂S
Molecular Weight:462.496
Hs Code.:

Synonyms:1-cyclohexyl-6-tosyl-2- (trifluoromethyl)-1,6- dihydroimidazo[4,5-d]pyrrolo[2,3- b]pyridine

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Chemical Property of 1-cyclohexyl-6-tosyl-2- (trifluoromethyl)-1,6- dihydroimidazo[4,5-d]pyrrolo[2,3- b]pyridine

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Technology Process of 1-cyclohexyl-6-tosyl-2- (trifluoromethyl)-1,6- dihydroimidazo[4,5-d]pyrrolo[2,3- b]pyridine

There total 9 articles about 1-cyclohexyl-6-tosyl-2- (trifluoromethyl)-1,6- dihydroimidazo[4,5-d]pyrrolo[2,3- b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1310730-50-7
N-(4-(cyclohexylamino)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,2,2-trifluoroacetamide

: 1310732-76-3
1-cyclohexyl-6-tosyl-2- (trifluoromethyl)-1,6- dihydroimidazo[4,5-d]pyrrolo[2,3- b]pyridine

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In N,N-dimethyl-formamide; at 100 ℃; for 16h;
DOI:10.1016/j.bmcl.2012.11.108

Reference yield:

: 417721-69-8
4-chloro-3-iodopyridin-2-ylamine

: 1310732-76-3
1-cyclohexyl-6-tosyl-2- (trifluoromethyl)-1,6- dihydroimidazo[4,5-d]pyrrolo[2,3- b]pyridine

Guidance literature:: Multi-step reaction with 9 steps

1: potassium nitrate; sulfuric acid / 15 h / -10 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 12 h / 50 °C

3: potassium fluoride / N,N-dimethyl-formamide / 4 h / 20 °C

4: chloro(1,5-cyclooctadiene)rhodium(I) dimer; P(p-C₆H₄F)3 / N,N-dimethyl-formamide / 2 h / 80 °C

5: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

7: tin(II) chloride dihdyrate / ethanol / 5 h / 75 °C

8: triethylamine / dichloromethane / 0.17 h / 0 - 20 °C

9: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 16 h / 100 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; copper(l) iodide; chloro(1,5-cyclooctadiene)rhodium(I) dimer; tin(II) chloride dihdyrate; sulfuric acid; sodium hydride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; potassium nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; P(p-C₆H₄F)3; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.108

Reference yield:

: 1310729-72-6
4-chloro-3-ethynyl-5-nitropyridin-2-amine

: 1310732-76-3
1-cyclohexyl-6-tosyl-2- (trifluoromethyl)-1,6- dihydroimidazo[4,5-d]pyrrolo[2,3- b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: chloro(1,5-cyclooctadiene)rhodium(I) dimer; P(p-C₆H₄F)3 / N,N-dimethyl-formamide / 2 h / 80 °C

2: sodium hydride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

4: tin(II) chloride dihdyrate / ethanol / 5 h / 75 °C

5: triethylamine / dichloromethane / 0.17 h / 0 - 20 °C

6: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 16 h / 100 °C

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; tin(II) chloride dihdyrate; sodium hydride; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; P(p-C₆H₄F)3; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.108