(1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine

Base Information

Chemical Name:(1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine
CAS No.:1027702-33-5
Molecular Formula:C₂₆H₂₇F₃N₂O
Molecular Weight:440.508
Hs Code.:

Synonyms:(1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine

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Technology Process of (1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine

There total 1 articles about (1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: rel-(3R,4S)-4-phenyl-1-(trifluoroacetyl)piperidine-3-carbaldehyde

: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

: 1027702-33-5
(1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine

Guidance literature:: rel-(3R,4S)-4-phenyl-1-(trifluoroacetyl)piperidine-3-carbaldehyde; (R)-1-(1-Naphthyl)ethylamine; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane; for 0.166667h;

Reference yield:

: 1027702-33-5
(1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine

: 1027682-72-9
(1R)-1-(1-naphthyl)-N-[(4-phenylpiperidin-3-yl)methyl]ethaneamine

Guidance literature:: With sodium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1027702-33-5
(1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine

: 1027702-60-8
tert-butyl [(1R)-1-(1-naphthyl)ethyl][(4-phenylpiperidin-3-yl)methyl]carbamate

Guidance literature:: di-tert-butyl dicarbonate; (1R)-1-(1-naphthyl)-N-{[4-phenyl-1-(trifluoroacetyl)piperidin-3-yl]methyl}ethaneamine; With triethylamine; In tetrahydrofuran; at 20 - 60 ℃;

With sodium hydroxide; water; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;