methyl 3-(2-fluorophenyl)-9-methoxy-8-(2-methoxyethoxy)-6H-benzo[c]chromene-2-carboxylate

Base Information

Chemical Name:methyl 3-(2-fluorophenyl)-9-methoxy-8-(2-methoxyethoxy)-6H-benzo[c]chromene-2-carboxylate
CAS No.:1428639-95-5
Molecular Formula:C₂₅H₂₃FO₆
Molecular Weight:438.452
Hs Code.:

Synonyms:methyl 3-(2-fluorophenyl)-9-methoxy-8-(2-methoxyethoxy)-6H-benzo[c]chromene-2-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 3-(2-fluorophenyl)-9-methoxy-8-(2-methoxyethoxy)-6H-benzo[c]chromene-2-carboxylate

Chemical Property:

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Technology Process of methyl 3-(2-fluorophenyl)-9-methoxy-8-(2-methoxyethoxy)-6H-benzo[c]chromene-2-carboxylate

There total 10 articles about methyl 3-(2-fluorophenyl)-9-methoxy-8-(2-methoxyethoxy)-6H-benzo[c]chromene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428639-93-3
methyl 3-(2-fluorophenyl)-8-hydroxy-9-methoxy-6H-benzo[c]chromene-2-carboxylate

: 6482-24-2
2-Bromoethyl methyl ether

: 1428639-95-5
methyl 3-(2-fluorophenyl)-9-methoxy-8-(2-methoxyethoxy)-6H-benzo[c]chromene-2-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 16h;

Reference yield:

: 1428639-86-4
methyl 2'-fluoro-5-nitrobiphenyl-2-carboxylate

: 1428639-95-5
methyl 3-(2-fluorophenyl)-9-methoxy-8-(2-methoxyethoxy)-6H-benzo[c]chromene-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: iron; acetic acid / 2 h / 85 °C

2: sulfuric acid; water; sodium nitrite / 19 h / 0 - 60 °C

3: potassium carbonate / acetone / 4 h / Reflux

4: bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl acetamide; potassium acetate / 40 h / 100 °C / Inert atmosphere

5: aluminum (III) chloride / dichloromethane / 2 h / 0 °C

6: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl acetamide; sulfuric acid; water; potassium acetate; iron; potassium carbonate; acetic acid; sodium nitrite; In dichloromethane; N,N-dimethyl-formamide; acetone; 4: |Sonogashira Cross-Coupling;

Reference yield:

: 1428639-87-5
methyl 5-amino-2'-fluorobiphenyl-2-carboxylate

: 1428639-95-5
methyl 3-(2-fluorophenyl)-9-methoxy-8-(2-methoxyethoxy)-6H-benzo[c]chromene-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; water; sodium nitrite / 19 h / 0 - 60 °C

2: potassium carbonate / acetone / 4 h / Reflux

3: bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl acetamide; potassium acetate / 40 h / 100 °C / Inert atmosphere

4: aluminum (III) chloride / dichloromethane / 2 h / 0 °C

5: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; N,N-dimethyl acetamide; sulfuric acid; water; potassium acetate; potassium carbonate; sodium nitrite; In dichloromethane; N,N-dimethyl-formamide; acetone; 3: |Sonogashira Cross-Coupling;