4-{[1-(3,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,3-dihydro-indol-2-one

Base Information

Chemical Name:4-{[1-(3,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,3-dihydro-indol-2-one
CAS No.:86162-92-7
Molecular Formula:C₁₈H₁₈N₂O₄
Molecular Weight:326.352
Hs Code.:

Synonyms:4-{[1-(3,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,3-dihydro-indol-2-one

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Chemical Property of 4-{[1-(3,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,3-dihydro-indol-2-one

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Technology Process of 4-{[1-(3,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,3-dihydro-indol-2-one

There total 4 articles about 4-{[1-(3,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,3-dihydro-indol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 54523-76-1
4-aminoindolin-2-one

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 86162-92-7
4-{[1-(3,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,3-dihydro-indol-2-one

Guidance literature:: With glacial acetic acid; In methanol; acetic acid;
DOI:10.1021/jo00163a006

Reference yield:

: 86162-89-2
dimethyl (2,6-dinitrophenyl)malonate

: 86162-92-7
4-{[1-(3,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,3-dihydro-indol-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / 70percent perchloric acid / acetic acid / 1 h / Heating

2: 94 percent / 10percent palladium on carbon, H₂ / methanol / 2.) reflux, 72 h

3: 96 percent / glacial acetic acid / methanol; acetic acid

With palladium on activated charcoal; perchloric acid; hydrogen; acetic acid; In methanol; acetic acid;
DOI:10.1021/jo00163a006

Reference yield:

: 606-21-3
1-chloro-2,6-dinitrobenzene

: 86162-92-7
4-{[1-(3,4,5-Trimethoxy-phenyl)-meth-(E)-ylidene]-amino}-1,3-dihydro-indol-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) potassium tert-butoxide / 1.)DMF, 2.) 20 to 90 deg C, 2 h, 25 deg C, 16 h, to 10 deg C

2: 70 percent / 70percent perchloric acid / acetic acid / 1 h / Heating

3: 94 percent / 10percent palladium on carbon, H₂ / methanol / 2.) reflux, 72 h

4: 96 percent / glacial acetic acid / methanol; acetic acid

With palladium on activated charcoal; perchloric acid; potassium tert-butylate; hydrogen; acetic acid; In methanol; acetic acid;
DOI:10.1021/jo00163a006