Technology Process of Ethyl 3-(3-amino-4-chlorophenyl)-3-methylbutanoate
There total 5 articles about Ethyl 3-(3-amino-4-chlorophenyl)-3-methylbutanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
ethyl acetate;
at 20 ℃;
under 750.075 Torr;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: magnesium / diethyl ether / 20 °C / Inert atmosphere
1.2: 3 h / -10 °C / Reflux
1.3: Cooling with ice
2.1: lithium chloride / water; dimethyl sulfoxide / 4 h / Reflux
3.1: nitronium tetrafluoborate / dichloromethane / 4 h / 0 - 10 °C
4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C / 750.08 Torr
With
nitronium tetrafluoborate; hydrogen; magnesium; lithium chloride;
palladium 10% on activated carbon;
In
diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: magnesium / diethyl ether / 20 °C / Inert atmosphere
1.2: 3 h / -10 °C / Reflux
1.3: Cooling with ice
2.1: lithium chloride / water; dimethyl sulfoxide / 4 h / Reflux
3.1: nitronium tetrafluoborate / dichloromethane / 4 h / 0 - 10 °C
4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C / 750.08 Torr
With
nitronium tetrafluoborate; hydrogen; magnesium; lithium chloride;
palladium 10% on activated carbon;
In
diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
