(1R,2R,3R,5R)-1-((S)-1-Cyano-2-phenyl-ethylamino)-5-isopropenyl-2-methyl-cyclohexane-1,3-dicarbonitrile

Base Information

• Chemical Name: (1R,2R,3R,5R)-1-((S)-1-Cyano-2-phenyl-ethylamino)-5-isopropenyl-2-methyl-cyclohexane-1,3-dicarbonitrile
• CAS No.: 155486-41-2
• Molecular Formula: C₂₁H₂₄N₄
• Molecular Weight: 332.448
• Mol file: 155486-41-2.mol

Synonyms:(1R,2R,3R,5R)-1-((S)-1-Cyano-2-phenyl-ethylamino)-5-isopropenyl-2-methyl-cyclohexane-1,3-dicarbonitrile

Chemical Property of (1R,2R,3R,5R)-1-((S)-1-Cyano-2-phenyl-ethylamino)-5-isopropenyl-2-methyl-cyclohexane-1,3-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,3R,5R)-1-((S)-1-Cyano-2-phenyl-ethylamino)-5-isopropenyl-2-methyl-cyclohexane-1,3-dicarbonitrile

There total 3 articles about (1R,2R,3R,5R)-1-((S)-1-Cyano-2-phenyl-ethylamino)-5-isopropenyl-2-methyl-cyclohexane-1,3-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-hydroxy-2-methylpropanenitrile (75-86-5) + (-)-1-(2-phenyl-ethylideneamino)-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile (155385-80-1) → (1R,2R,3R,5R)-1-((S)-1-Cyano-2-phenyl-ethylamino)-5-isopropenyl-2-methyl-cyclohexane-1,3-dicarbonitrile (155486-41-2) + (-)-1-<(1-cyano-2-phenylethyl)amino>-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile (155385-83-4)

Guidance literature:

In methanol; for 32h; Heating;

Reference yield:

(-)-(1R,2R,5R)-2-methyl-5-(1-methylethenyl)-3-oxocyclohexanecarbonitrile (137625-67-3) → (1R,2R,3R,5R)-1-((S)-1-Cyano-2-phenyl-ethylamino)-5-isopropenyl-2-methyl-cyclohexane-1,3-dicarbonitrile (155486-41-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium chloride / aq. NH₃; H₂O; methanol / 24 h

2: 91 percent / Na₂SO₄ / CHCl₃ / 24 h / Heating

3: 14 percent / methanol / 32 h / Heating

With ammonium chloride; sodium sulfate; In methanol; ammonium hydroxide; chloroform; water;

Reference yield:

(-)-1-amino-2R-methyl-5R-(1-methylethenyl)cyclohexane-1,3R-dicarbonitrile (155385-79-8) → (1R,2R,3R,5R)-1-((S)-1-Cyano-2-phenyl-ethylamino)-5-isopropenyl-2-methyl-cyclohexane-1,3-dicarbonitrile (155486-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / Na₂SO₄ / CHCl₃ / 24 h / Heating

2: 14 percent / methanol / 32 h / Heating

With sodium sulfate; In methanol; chloroform;

upstream raw materials:

2-hydroxy-2-methylpropanenitrile

(-)-1-(2-phenyl-ethylideneamino)-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile

(-)-(1R,2R,5R)-2-methyl-5-(1-methylethenyl)-3-oxocyclohexanecarbonitrile

(-)-1-amino-2R-methyl-5R-(1-methylethenyl)cyclohexane-1,3R-dicarbonitrile

Downstream raw materials:

L-phenylalanine