Methyl 4-methyl-3-[2-(4-methyl-piperazin-1-ylmethyl)-pyrimidin-4-yloxy]-benzoate

Base Information

Chemical Name:Methyl 4-methyl-3-[2-(4-methyl-piperazin-1-ylmethyl)-pyrimidin-4-yloxy]-benzoate
CAS No.:1215031-47-2
Molecular Formula:C₁₉H₂₄N₄O₃
Molecular Weight:356.425
Hs Code.:

Synonyms:Methyl 4-methyl-3-[2-(4-methyl-piperazin-1-ylmethyl)-pyrimidin-4-yloxy]-benzoate

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Chemical Property of Methyl 4-methyl-3-[2-(4-methyl-piperazin-1-ylmethyl)-pyrimidin-4-yloxy]-benzoate

Chemical Property:

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Technology Process of Methyl 4-methyl-3-[2-(4-methyl-piperazin-1-ylmethyl)-pyrimidin-4-yloxy]-benzoate

There total 4 articles about Methyl 4-methyl-3-[2-(4-methyl-piperazin-1-ylmethyl)-pyrimidin-4-yloxy]-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215031-49-4
4-chloro-2-(4-methyl-piperazin-1-ylmethyl)-pyrimidine

: 3556-86-3
methyl 4-methyl-3-hydroxybenzoate

: 1215031-47-2
Methyl 4-methyl-3-[2-(4-methyl-piperazin-1-ylmethyl)-pyrimidin-4-yloxy]-benzoate

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; Inert atmosphere;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1215031-47-2
Methyl 4-methyl-3-[2-(4-methyl-piperazin-1-ylmethyl)-pyrimidin-4-yloxy]-benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: propan-1-ol / 4.5 h / Reflux

2: trichlorophosphate / acetonitrile / 0.17 h / Reflux

3: potassium tert-butylate / dimethyl sulfoxide / 20 °C / Inert atmosphere

With potassium tert-butylate; trichlorophosphate; In propan-1-ol; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 4-hydroxy-2-chloromethylpyrimidine

: 1215031-47-2
Methyl 4-methyl-3-[2-(4-methyl-piperazin-1-ylmethyl)-pyrimidin-4-yloxy]-benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: propan-1-ol / 4.5 h / Reflux

2: trichlorophosphate / acetonitrile / 0.17 h / Reflux

3: potassium tert-butylate / dimethyl sulfoxide / 20 °C / Inert atmosphere

With potassium tert-butylate; trichlorophosphate; In propan-1-ol; dimethyl sulfoxide; acetonitrile;