(1S,2R)-1-fluoro-3-methyl-1-phenylbutan-2-amine

Base Information

• Chemical Name: (1S,2R)-1-fluoro-3-methyl-1-phenylbutan-2-amine
• CAS No.: 1311404-17-7
• Molecular Formula: C₁₁H₁₆FN
• Molecular Weight: 181.253
• Mol file: 1311404-17-7.mol

Synonyms:(1S,2R)-1-fluoro-3-methyl-1-phenylbutan-2-amine

Chemical Property of (1S,2R)-1-fluoro-3-methyl-1-phenylbutan-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-1-fluoro-3-methyl-1-phenylbutan-2-amine

There total 4 articles about (1S,2R)-1-fluoro-3-methyl-1-phenylbutan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

{N-[(1S,2R)-1-fluoro-3-methyl-1-{2-[(S)-p-tolylsulfinyl]phenyl}]butan-2-yl}-(S)-p-tolylsulfinamide (1311404-10-0) → (1S,2R)-1-fluoro-3-methyl-1-phenylbutan-2-amine (1311404-17-7)

Guidance literature:

{N-[(1S,2R)-1-fluoro-3-methyl-1-{2-[(S)-p-tolylsulfinyl]phenyl}]butan-2-yl}-(S)-p-tolylsulfinamide; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; Inert atmosphere;

With water; In tetrahydrofuran; pentane; Inert atmosphere;

DOI:10.1002/chem.201100455

Reference yield:

(S)‐2‐(p‐tolylsulfinyl)benzyl 4‐methylbenzenesulfonate (1311404-15-5) → (1S,2R)-1-fluoro-3-methyl-1-phenylbutan-2-amine (1311404-17-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: cesium fluoride / acetonitrile / 80 °C / Inert atmosphere; Ionic liquid

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / -78 °C / Inert atmosphere

3.2: Inert atmosphere

With tert.-butyl lithium; cesium fluoride; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetonitrile; pentane;

DOI:10.1002/chem.201100455

Reference yield:

(S)‐(2‐(p‐tolylsulfinyl)phenyl)methanol (59153-49-0) → (1S,2R)-1-fluoro-3-methyl-1-phenylbutan-2-amine (1311404-17-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

2.1: cesium fluoride / acetonitrile / 80 °C / Inert atmosphere; Ionic liquid

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

3.2: -78 °C / Inert atmosphere

3.3: Inert atmosphere

4.1: tert.-butyl lithium / tetrahydrofuran; pentane / -78 °C / Inert atmosphere

4.2: Inert atmosphere

With tert.-butyl lithium; cesium fluoride; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetonitrile; pentane;

DOI:10.1002/chem.201100455

upstream raw materials:

{N-[(1S,2R)-1-fluoro-3-methyl-1-{2-[(S)-p-tolylsulfinyl]phenyl}]butan-2-yl}-(S)-p-tolylsulfinamide

(S)‐2‐(p‐tolylsulfinyl)benzyl 4‐methylbenzenesulfonate

1-(fluoromethyl)-2-[(S)-p-tolylsulfinyl]benzene

(S)‐(2‐(p‐tolylsulfinyl)phenyl)methanol