9-(2'-O-tetrahydropyranyl-5'-O-(dimethoxytrityl)-β-D-ribofuranosyl)hypoxanthine

Base Information

Chemical Name:9-(2'-O-tetrahydropyranyl-5'-O-(dimethoxytrityl)-β-D-ribofuranosyl)hypoxanthine
CAS No.:126647-53-8
Molecular Formula:C₃₆H₃₈N₄O₈
Molecular Weight:654.72
Hs Code.:

Synonyms:9-(2'-O-tetrahydropyranyl-5'-O-(dimethoxytrityl)-β-D-ribofuranosyl)hypoxanthine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-(2'-O-tetrahydropyranyl-5'-O-(dimethoxytrityl)-β-D-ribofuranosyl)hypoxanthine

Chemical Property:

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Technology Process of 9-(2'-O-tetrahydropyranyl-5'-O-(dimethoxytrityl)-β-D-ribofuranosyl)hypoxanthine

There total 6 articles about 9-(2'-O-tetrahydropyranyl-5'-O-(dimethoxytrityl)-β-D-ribofuranosyl)hypoxanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 126647-51-6,126647-52-7
2'-O-tetrahydropyranylinosine

: 126647-53-8
5'-O-dimethoxytrityl-2'-O-tetrahydropyranylinosine

Guidance literature:: With pyridine; 4,4'-dimethoxytrityl chloride; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 95.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 126647-51-6,126647-52-7
2'-O-tetrahydropyranylinosine

: 126647-53-8
5'-O-dimethoxytrityl-2'-O-tetrahydropyranylinosine

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/acs.jmedchem.6b01300

Reference yield:

: 58-63-9
Inosine

: 126647-53-8
5'-O-dimethoxytrityl-2'-O-tetrahydropyranylinosine

Guidance literature:: Multi-step reaction with 4 steps

1: 81 percent / 3 h / 35 °C

2: p-toluenesulfonic acid / CH₂Cl₂ / 40 h

3: 1 M tetrabutylammonium fluoride / tetrahydrofuran / 1 h

4: 76.4 percent / 2 h

With tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;