4-({4-[(11β,17β)-17-hydroxy-3-oxo-17-(pentafluoroethyl)estra-4,9-dien-11-yl]benzyl}amino)benzenesulphonamide

Base Information

Chemical Name:4-({4-[(11β,17β)-17-hydroxy-3-oxo-17-(pentafluoroethyl)estra-4,9-dien-11-yl]benzyl}amino)benzenesulphonamide
CAS No.:1325203-88-0
Molecular Formula:C₃₃H₃₅F₅N₂O₄S
Molecular Weight:650.71
Hs Code.:

Synonyms:4-({4-[(11β,17β)-17-hydroxy-3-oxo-17-(pentafluoroethyl)estra-4,9-dien-11-yl]benzyl}amino)benzenesulphonamide

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Chemical Property of 4-({4-[(11β,17β)-17-hydroxy-3-oxo-17-(pentafluoroethyl)estra-4,9-dien-11-yl]benzyl}amino)benzenesulphonamide

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Technology Process of 4-({4-[(11β,17β)-17-hydroxy-3-oxo-17-(pentafluoroethyl)estra-4,9-dien-11-yl]benzyl}amino)benzenesulphonamide

There total 4 articles about 4-({4-[(11β,17β)-17-hydroxy-3-oxo-17-(pentafluoroethyl)estra-4,9-dien-11-yl]benzyl}amino)benzenesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 622404-66-4
4-[(17β)-20,20,21,21,21-pentafluoro-17-hydroxy-3-oxo-19-norpregna-4,9-dien-11-yl]benzaldehyde

: 63-74-1
sulfanilamide

: 1325203-88-0
4-({4-[(11β,17β)-17-hydroxy-3-oxo-17-(pentafluoroethyl)estra-4,9-dien-11-yl]benzyl}amino)benzenesulphonamide

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; 1,2-dichloro-ethane; at 50 ℃; for 12h;

Reference yield:

: 91175-93-8
(5′R,8′S,10′R,13′S,14′S)-5,5,13′-trimethyl-1′,2′,6′,7′,8′,12′,13′,14′,15′,16′-decahydro-17′H-spiro[1,3-dioxane-2,3′-[5,10]epoxycyclopenta[a]phenanthren]-17′-one

: 1325203-88-0
4-({4-[(11β,17β)-17-hydroxy-3-oxo-17-(pentafluoroethyl)estra-4,9-dien-11-yl]benzyl}amino)benzenesulphonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: methyllithium lithium bromide / toluene; diethyl ether / 1 h / -70 - 0 °C

2.1: magnesium / tetrahydrofuran / 1 h / 40 - 50 °C

2.2: 0.25 h / 0 °C

2.3: 13 h / 23 °C

3.1: acetic acid / 16 h / 30 °C

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane; tetrahydrofuran / 12 h / 50 °C

With methyllithium lithium bromide; sodium tris(acetoxy)borohydride; magnesium; acetic acid; In tetrahydrofuran; diethyl ether; 1,2-dichloro-ethane; toluene;

Reference yield:

: 1026668-61-0
(5′R,8′S,10′R,13′S,14′S,17′S)-5,5,13′-trimethyl-17′-(pentafluoroethyl)-1′,2′,7′,8′,12′,13′,14′,15′,16′,17′-decahydro-6′H-spiro[1,3-dioxane-2,3′-[5,10]epoxycyclopenta[a]phenanthren]-17′-ol

: 1325203-88-0
4-({4-[(11β,17β)-17-hydroxy-3-oxo-17-(pentafluoroethyl)estra-4,9-dien-11-yl]benzyl}amino)benzenesulphonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium / tetrahydrofuran / 1 h / 40 - 50 °C

1.2: 0.25 h / 0 °C

1.3: 13 h / 23 °C

2.1: acetic acid / 16 h / 30 °C

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane; tetrahydrofuran / 12 h / 50 °C

With sodium tris(acetoxy)borohydride; magnesium; acetic acid; In tetrahydrofuran; 1,2-dichloro-ethane;