2,6-dichloro-N-[2-(4-hydroxypiperidin-1-yl)ethyl]benzamide

Base Information

• Chemical Name: 2,6-dichloro-N-[2-(4-hydroxypiperidin-1-yl)ethyl]benzamide
• CAS No.: 948895-18-9
• Molecular Formula: C₁₄H₁₈Cl₂N₂O₂
• Molecular Weight: 317.215
• Mol file: 948895-18-9.mol

Synonyms:2,6-dichloro-N-[2-(4-hydroxypiperidin-1-yl)ethyl]benzamide

Chemical Property of 2,6-dichloro-N-[2-(4-hydroxypiperidin-1-yl)ethyl]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dichloro-N-[2-(4-hydroxypiperidin-1-yl)ethyl]benzamide

There total 1 articles about 2,6-dichloro-N-[2-(4-hydroxypiperidin-1-yl)ethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-aminoethyl)-4-hydroxypiperidine (129999-60-6) + 2,6-dichlorobenzoic acid (50-30-6) → 2,6-dichloro-N-[2-(4-hydroxypiperidin-1-yl)ethyl]benzamide (948895-18-9)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 14h;

Reference yield:

2,6-dichloro-N-[2-(4-hydroxypiperidin-1-yl)ethyl]benzamide (948895-18-9) → 2,6-dichloro-N-[2-(4-oxopiperidin-1-yl)ethyl]benzamide (948895-19-0)

Guidance literature:

With Jones reagent; In water; acetone; at 0 - 20 ℃; for 14h;

Reference yield:

2,6-dichloro-N-[2-(4-hydroxypiperidin-1-yl)ethyl]benzamide (948895-18-9) → 2,6-dichloro-N-[2-(4-{[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}piperidin-1-yl)ethyl]benzamide

Guidance literature:

Multi-step reaction with 3 steps

1: Jones reagent / water; acetone / 14 h / 0 - 20 °C

2: sodium tris(acetoxy)borohydride; acetic acid / 1-methyl-pyrrolidin-2-one / 14 h / 20 °C

3: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 14 h / 20 °C

With Jones reagent; sodium tris(acetoxy)borohydride; acetic acid; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; water; acetone;

upstream raw materials:

N-(2-aminoethyl)-4-hydroxypiperidine

2,6-dichlorobenzoic acid

Downstream raw materials:

2,6-dichloro-N-[2-(4-oxopiperidin-1-yl)ethyl]benzamide