(Z)-7-{(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-methylamino-cyclopentyl}-hept-5-enoic acid amide

Base Information

Chemical Name:(Z)-7-{(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-methylamino-cyclopentyl}-hept-5-enoic acid amide
CAS No.:85453-56-1
Molecular Formula:C₃₉H₇₀N₂O₅SSi₂
Molecular Weight:735.232
Hs Code.:

(Z)-7-{(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-methylamino-cyclopentyl}-hept-5-enoic acid amide

Synonyms:(Z)-7-{(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-methylamino-cyclopentyl}-hept-5-enoic acid amide

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Chemical Property of (Z)-7-{(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-methylamino-cyclopentyl}-hept-5-enoic acid amide

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Technology Process of (Z)-7-{(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-methylamino-cyclopentyl}-hept-5-enoic acid amide

There total 3 articles about (Z)-7-{(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-methylamino-cyclopentyl}-hept-5-enoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 85453-54-9
(Z)-7-{(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-methylamino-cyclopentyl}-hept-5-enenitrile

: 85453-56-1
(Z)-7-{(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-methylamino-cyclopentyl}-hept-5-enoic acid amide

Guidance literature:: With potassium hydroxide; dihydrogen peroxide; ethanolamine; In 2-methoxy-ethanol; water; for 4h;
DOI:10.1021/jo00161a010

Reference yield:

: 85453-53-8
[(1S,2R,3S,4R)-2-Benzenesulfonyl-4-(tert-butyl-dimethyl-silanyloxy)-3-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-((Z)-6-cyano-hex-2-enyl)-cyclopentyl]-methyl-carbamic acid 2,2,2-trichloro-ethyl ester

: 85453-56-1
(Z)-7-{(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-methylamino-cyclopentyl}-hept-5-enoic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / zinc / tetrahydrofuran / 6 h / 65 °C

2: 94 percent / KOH, ethanolamine, 30percent H₂O₂ / H₂O; 2-methoxy-ethanol / 4 h

With potassium hydroxide; dihydrogen peroxide; ethanolamine; zinc; In tetrahydrofuran; 2-methoxy-ethanol; water;
DOI:10.1021/jo00161a010

Reference yield:

: 85453-26-5
(Z)-7-{(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-dimethylamino-cyclopentyl}-hept-5-enenitrile

: 85453-56-1
(Z)-7-{(1R,2S,3R,5S)-1-Benzenesulfonyl-3-(tert-butyl-dimethyl-silanyloxy)-2-[(E)-(S)-3-(tert-butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-methylamino-cyclopentyl}-hept-5-enoic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / NaHCO₃ / CH₂Cl₂ / 72 h / 25 °C

2: 94 percent / zinc / tetrahydrofuran / 6 h / 65 °C

3: 94 percent / KOH, ethanolamine, 30percent H₂O₂ / H₂O; 2-methoxy-ethanol / 4 h

With potassium hydroxide; dihydrogen peroxide; sodium hydrogencarbonate; ethanolamine; zinc; In tetrahydrofuran; dichloromethane; 2-methoxy-ethanol; water;
DOI:10.1021/jo00161a010