((5,8-bisbenzyloxy-2-chloro-4-3S,4R,5R,6R-3,4,5-trisbenzyloxy-6-benzyloxymethyltetrahydro-2H-pyran-2-ylnaphthalen-1-yloxy)methyl)4-tert-butyldimethylsilyloxymethyl-5-(methylthio)furan-2-yldimethylsilane

Base Information

Chemical Name:((5,8-bisbenzyloxy-2-chloro-4-3S,4R,5R,6R-3,4,5-trisbenzyloxy-6-benzyloxymethyltetrahydro-2H-pyran-2-ylnaphthalen-1-yloxy)methyl)4-tert-butyldimethylsilyloxymethyl-5-(methylthio)furan-2-yldimethylsilane
CAS No.:1258381-45-1
Molecular Formula:C₇₃H₈₁ClO₁₀SSi₂
Molecular Weight:1242.13
Hs Code.:

((5,8-bisbenzyloxy-2-chloro-4-3S,4R,5R,6R-3,4,5-trisbenzyloxy-6-benzyloxymethyltetrahydro-2H-pyran-2-ylnaphthalen-1-yloxy)methyl)4-tert-butyldimethylsilyloxymethyl-5-(methylthio)furan-2-yldimethylsilane

Synonyms:((5,8-bisbenzyloxy-2-chloro-4-3S,4R,5R,6R-3,4,5-trisbenzyloxy-6-benzyloxymethyltetrahydro-2H-pyran-2-ylnaphthalen-1-yloxy)methyl)4-tert-butyldimethylsilyloxymethyl-5-(methylthio)furan-2-yldimethylsilane

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Chemical Property of ((5,8-bisbenzyloxy-2-chloro-4-3S,4R,5R,6R-3,4,5-trisbenzyloxy-6-benzyloxymethyltetrahydro-2H-pyran-2-ylnaphthalen-1-yloxy)methyl)4-tert-butyldimethylsilyloxymethyl-5-(methylthio)furan-2-yldimethylsilane

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Technology Process of ((5,8-bisbenzyloxy-2-chloro-4-3S,4R,5R,6R-3,4,5-trisbenzyloxy-6-benzyloxymethyltetrahydro-2H-pyran-2-ylnaphthalen-1-yloxy)methyl)4-tert-butyldimethylsilyloxymethyl-5-(methylthio)furan-2-yldimethylsilane

There total 10 articles about ((5,8-bisbenzyloxy-2-chloro-4-3S,4R,5R,6R-3,4,5-trisbenzyloxy-6-benzyloxymethyltetrahydro-2H-pyran-2-ylnaphthalen-1-yloxy)methyl)4-tert-butyldimethylsilyloxymethyl-5-(methylthio)furan-2-yldimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1258381-54-2
4-tert-butyldimethylsilyloxymethyl-5-(methylthio)furan-2-yldimethylsilylmethanol

: 1258381-47-3
5,8-bisbenzyloxy-2-chloro-4-3S,4R,5R,6R-3,4,5-trisbenzyloxy-6-benzyloxymethyltetrahydro-2H-pyran-2-ylnaphthalen-1-ol

: 1258381-45-1
((5,8-bisbenzyloxy-2-chloro-4-3S,4R,5R,6R-3,4,5-trisbenzyloxy-6-benzyloxymethyltetrahydro-2H-pyran-2-ylnaphthalen-1-yloxy)methyl)4-tert-butyldimethylsilyloxymethyl-5-(methylthio)furan-2-yldimethylsilane

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 20h;
DOI:10.1021/ol102318k

Reference yield:

: 1258381-49-5
C₅₈H₅₄O₈

: 1258381-45-1
((5,8-bisbenzyloxy-2-chloro-4-3S,4R,5R,6R-3,4,5-trisbenzyloxy-6-benzyloxymethyltetrahydro-2H-pyran-2-ylnaphthalen-1-yloxy)methyl)4-tert-butyldimethylsilyloxymethyl-5-(methylthio)furan-2-yldimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1: zinc(II) chloride / dichloromethane / 14 h

2: N-chloro-succinimide / N,N-dimethyl-formamide / 16 h

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 h / 20 °C

With N-chloro-succinimide; di-isopropyl azodicarboxylate; triphenylphosphine; zinc(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Mitsunobu reaction;
DOI:10.1021/ol102318k

Reference yield:

: 615-67-8
chloro-p-hydroquinone

: 1258381-45-1
((5,8-bisbenzyloxy-2-chloro-4-3S,4R,5R,6R-3,4,5-trisbenzyloxy-6-benzyloxymethyltetrahydro-2H-pyran-2-ylnaphthalen-1-yloxy)methyl)4-tert-butyldimethylsilyloxymethyl-5-(methylthio)furan-2-yldimethylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 24 h / 20 °C

2.1: (2-methylpropyl)lithium / tetrahydrofuran; cyclohexane / -100 °C

2.2: 0.75 h / -100 - -20 °C

3.1: zinc(II) chloride / dichloromethane / 14 h

4.1: N-chloro-succinimide / N,N-dimethyl-formamide / 16 h

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 h / 20 °C

With N-chloro-succinimide; di-isopropyl azodicarboxylate; (2-methylpropyl)lithium; sodium hydride; triphenylphosphine; zinc(II) chloride; In tetrahydrofuran; dichloromethane; cyclohexane; N,N-dimethyl-formamide; mineral oil; 5.1: Mitsunobu reaction;
DOI:10.1021/ol102318k