Benzyl α-(Triphenylphosphoranylidene)-α-{5-(tert-butoxycarbonyl)-4-[2'-(methoxycarbonyl)ethyl]-3-methylpyrrol-2-yl}acetate

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Chemical Name:Benzyl α-(Triphenylphosphoranylidene)-α-{5-(tert-butoxycarbonyl)-4-[2'-(methoxycarbonyl)ethyl]-3-methylpyrrol-2-yl}acetate
CAS No.:64056-73-1
Molecular Formula:C₄₁H₄₂NO₆P
Molecular Weight:675.761
Hs Code.:

Synonyms:Benzyl α-(Triphenylphosphoranylidene)-α-{5-(tert-butoxycarbonyl)-4-[2'-(methoxycarbonyl)ethyl]-3-methylpyrrol-2-yl}acetate

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Chemical Property of Benzyl α-(Triphenylphosphoranylidene)-α-{5-(tert-butoxycarbonyl)-4-[2'-(methoxycarbonyl)ethyl]-3-methylpyrrol-2-yl}acetate

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Technology Process of Benzyl α-(Triphenylphosphoranylidene)-α-{5-(tert-butoxycarbonyl)-4-[2'-(methoxycarbonyl)ethyl]-3-methylpyrrol-2-yl}acetate

There total 11 articles about Benzyl α-(Triphenylphosphoranylidene)-α-{5-(tert-butoxycarbonyl)-4-[2'-(methoxycarbonyl)ethyl]-3-methylpyrrol-2-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2769-72-4
tert-Butyl isocyanoacetate

: 64056-73-1
Benzyl α-(Triphenylphosphoranylidene)-α-{5-(tert-butoxycarbonyl)-4-[2'-(methoxycarbonyl)ethyl]-3-methylpyrrol-2-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: DBU / acetonitrile

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;
DOI:10.1002/(SICI)1521-3773(19980803)37:13/14<1843::AID-ANIE1843>3.0.CO;2-W

Reference yield:

: (E)-5-Nitro-pent-4-enoic acid methyl ester

: 64056-73-1
Benzyl α-(Triphenylphosphoranylidene)-α-{5-(tert-butoxycarbonyl)-4-[2'-(methoxycarbonyl)ethyl]-3-methylpyrrol-2-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: DBU / acetonitrile

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;
DOI:10.1002/(SICI)1521-3773(19980803)37:13/14<1843::AID-ANIE1843>3.0.CO;2-W

Reference yield:

: 31837-48-6
t-butyl 5-iodo-3-(2-methoxycarbonylethyl)-4-methylpyrrole-2-carboxylate

: 64056-73-1
Benzyl α-(Triphenylphosphoranylidene)-α-{5-(tert-butoxycarbonyl)-4-[2'-(methoxycarbonyl)ethyl]-3-methylpyrrol-2-yl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / H₂, MgO / PtO₂ / methanol / 2585.7 Torr

2: 86 percent / ZnCl₂ / CH₂Cl₂ / 8 h / Ambient temperature

3: 1)N-chlorosuccinimide, dimethylsulfide / 1) CH₂Cl₂, 5 deg C, 12 h, 2) CH₂Cl₂, room temp., 24 h

4: Na₂CO₃

With N-chloro-succinimide; dimethylsulfide; hydrogen; magnesium oxide; sodium carbonate; zinc(II) chloride; platinum(IV) oxide; In methanol; dichloromethane;
DOI:10.1021/jo00017a017