2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>propionitrile

Base Information

Chemical Name:2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>propionitrile
CAS No.:150461-51-1
Molecular Formula:C₃₃H₂₈ClN₃OS
Molecular Weight:550.124
Hs Code.:

Synonyms:2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>propionitrile

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Chemical Property of 2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>propionitrile

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Technology Process of 2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>propionitrile

There total 12 articles about 2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 143-33-9,25596-52-5
sodium cyanide

: 150461-50-0
2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>ethanol methanesulfonate

: 150461-51-1
2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>propionitrile

Guidance literature:: In dimethyl sulfoxide; N,N-dimethyl-formamide; at 125 ℃; for 1h;
DOI:10.1021/jm00071a008

Reference yield:

: 3256-88-0
5-phenyl-2-picoline

: 150461-51-1
2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>propionitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / N-chlorosuccinimide, benzoyl peroxide / CCl₄ / 5 h / Heating; Irradiation

2: NaH / dimethylformamide / 1 h

3: 95 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

4: 100 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

5: 45 percent / dimethylformamide; dimethylsulfoxide / 1 h / 125 °C

With N-chloro-succinimide; lithium aluminium tetrahydride; Perbenzoic acid; sodium hydride; triethylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a008

Reference yield:

: 146775-28-2
2-chloromethyl-5-phenylpyridine

: 150461-51-1
2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>propionitrile

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylformamide / 1 h

2: 95 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3: 100 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 45 percent / dimethylformamide; dimethylsulfoxide / 1 h / 125 °C

With lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a008