Technology Process of 2-(2-Fluoro-5-hydroxy-4-trifluoromethylsulfonamidophenyl)benzothiazole
There total 6 articles about 2-(2-Fluoro-5-hydroxy-4-trifluoromethylsulfonamidophenyl)benzothiazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
methanol;
for 0.5h;
Heating;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 76 percent / pyridine / 1 h / Heating
2: 85 percent / SnCl2*2H2O / ethanol / 4 h / Heating
3: 1.) aq. HCl, NaNO2, 2.) aq. NaN3 / 1.) 0-5 deg C, 20 min, 2.) 0-5 deg C, 2 h
4: 31 percent / TFA, TFAA, CF3SO3H / 1.) 0 deg C, 30 min, 2.) r.t., 18 h
5: 75 percent / 10percent aq. KOH / methanol / 0.5 h / Heating
With
pyridine; hydrogenchloride; potassium hydroxide; sodium azide; trifluorormethanesulfonic acid; trifluoroacetic acid; trifluoroacetic anhydride; tin(ll) chloride; sodium nitrite;
In
methanol; ethanol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 76 percent / pyridine / 1 h / Heating
2: 85 percent / SnCl2*2H2O / ethanol / 4 h / Heating
3: 1.) aq. HCl, NaNO2, 2.) aq. NaN3 / 1.) 0-5 deg C, 20 min, 2.) 0-5 deg C, 2 h
4: 31 percent / TFA, TFAA, CF3SO3H / 1.) 0 deg C, 30 min, 2.) r.t., 18 h
5: 75 percent / 10percent aq. KOH / methanol / 0.5 h / Heating
With
pyridine; hydrogenchloride; potassium hydroxide; sodium azide; trifluorormethanesulfonic acid; trifluoroacetic acid; trifluoroacetic anhydride; tin(ll) chloride; sodium nitrite;
In
methanol; ethanol;
