Technology Process of USC-O401
There total 7 articles about USC-O401 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(2-Methoxyphenyl)piperazine;
With
potassium carbonate;
In
4-methyl-2-pentanone;
for 1h;
Inert atmosphere;
Reflux;
2-(4-chlorobutyl)-3,4-dihydro-6-ethynylisoquinolin-1(2H)-one;
With
potassium iodide;
In
4-methyl-2-pentanone;
for 48h;
Reflux;
DOI:10.1016/j.bmcl.2010.12.083
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium azide / methanesulfonic acid; dichloromethane / 0 - 20 °C
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 15 h / 20 °C
4.1: sodium hydride / benzene / 1 h / Reflux; Inert atmosphere
4.2: 20 °C / Inert atmosphere; Reflux
5.1: potassium carbonate / 4-methyl-2-pentanone / 1 h / Inert atmosphere; Reflux
5.2: 48 h / Reflux
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; sodium hydride; potassium carbonate; triethylamine;
In
tetrahydrofuran; methanesulfonic acid; dichloromethane; 4-methyl-2-pentanone; benzene;
1.1: Schmidt reaction / 2.1: Sonogashira coupling;
DOI:10.1016/j.bmcl.2010.12.083
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 15 h / 20 °C
3.1: sodium hydride / benzene / 1 h / Reflux; Inert atmosphere
3.2: 20 °C / Inert atmosphere; Reflux
4.1: potassium carbonate / 4-methyl-2-pentanone / 1 h / Inert atmosphere; Reflux
4.2: 48 h / Reflux
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; potassium carbonate; triethylamine;
In
tetrahydrofuran; 4-methyl-2-pentanone; benzene;
1.1: Sonogashira coupling;
DOI:10.1016/j.bmcl.2010.12.083
